DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tdc2 and b

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_001246025.1	Gene:	b / 34791	FlyBaseID:	FBgn0000153	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	119/475 - (25%)
Similarity:	200/475 - (42%)	Gaps:	60/475 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 EPGYLRHLLPPEAPQEPEDWDQIMRDVEDKIMPGVTHWQHPRFHAYFPAGNSFPSILGDMLGDGI 98
            ||..||.|...:..::.|..|::...:.:.|...| ...||.|.....:|....:::|..|.|.:
  Fly   127 EPAELRQLFDFQLREQGESQDKLRELLRETIRFSV-KTGHPYFINQLYSGVDPYALVGQWLTDAL 190

  Fly    99 GCIGFSWAASPACTELETIVLDWLGKAIGLPDHFLALKEGSTGGGVIQTSASECVLVTMLAARAQ 163
            ....:::..:|..|.:|..||..:.:.:|.|:       |..|.|:.....|        .|...
  Fly   191 NPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPN-------GGQGDGIFCPGGS--------IANGY 240

  Fly   164 ALKRLKAQH-PFVEEGHLLS--KLMAYCSKEAHSCVEKAAMICFV-----KLRILEPDDDASLRG 220
            |:...:.:| |..::..|.:  .|:.:.|::||..|||.||  |:     .:|.:..::...:|.
  Fly   241 AISCARYRHSPESKKNGLFNAKPLIIFTSEDAHYSVEKLAM--FMGFGSDHVRKIATNEVGKMRL 303

  Fly   221 QTIYEAMEEDELQGLVPFFVSTTLGTTGSCAFDNLPEIGKQLQRFPGVWLHVDAAYAGNSFICPE 285
            ..:.:.::.....|..|..||.|.|||...|||:|..|.:..::: .:|:|||||:.|.:.:..:
  Fly   304 SDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKY-NMWMHVDAAWGGGALMSKK 367

  Fly   286 LKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWVRDRIRLTSALVVDPLYL--KHGYSDAAIDYRH 348
            .:.||.|||.|||...||:|.|..:..|||...|.:..|......:..||  |..:.|.:.|...
  Fly   368 YRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDKFYDTSFDTGD 432

  Fly   349 WGVPLSRRFRSLKLWFVLRSYGISGLQHYIRHHIKLAKRFEELVLKDKRFEI------CNQVKLG 407
            ..:...||....|.||:.::.|..||:.::....::|:.|...|.:...||:      |..:...
  Fly   433 KHIQCGRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVLESPECTNISFW 497

  Fly   408 LVCFRLKGSDKLNEKLLSIINESGKLHMVPASVGDRYIIR----------------FCAVAQNAT 456
            .|...|:..::..|..       .:||.|...|.:..|.:                |..|.||:.
  Fly   498 YVPPGLREMERNREFY-------DRLHKVAPKVKEGMIKKGSMMITYQPLRQLPNFFRLVLQNSC 555

  Fly   457 AEDID--YAWDIIVDFANEL 474
            .|:.|  |..|.|...|..|
  Fly   556 LEESDMVYFLDEIESLAQNL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	100/394 (25%)
b	NP_001246025.1	AAT_I	128..499	CDD:302748	99/389 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445355
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830