DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tdc2 and GADL1

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_997242.2	Gene:	GADL1 / 339896	HGNCID:	27949	Length:	521	Species:	Homo sapiens

Alignment Length:	527	Identity:	134/527 - (25%)
Similarity:	219/527 - (41%)	Gaps:	105/527 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KRGMEMVEYICNYL--------ETLNERRVTPSVEPGYLRHLLPPE---APQEPEDWDQIMRDVE 61
            |.|.:.||..|..:        ..:|| :|.....|..|:.||..|   :.:.|....::.||
Human    43 KAGEKFVEEACRLIMEEVVLKATDVNE-KVCEWRPPEQLKQLLDLEMRDSGEPPHKLLELCRD-- 104

  Fly    62 DKIMPGVTHW----QHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWL 122
                  |.|:    .||||.....||..:.|::...:.:.:....:::..||....:|..||.
Human   105 ------VIHYSVKTNHPRFFNQLYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAVLK-- 161

  Fly   123 GKAIGLPDHFLALKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHLLS---KL 184
             |.|    .|:..|||.   |:.....|...:..|..||.:....:|      |:|  ||   :|
Human   162 -KMI----EFIGWKEGD---GIFNPGGSVSNMYAMNLARYKYCPDIK------EKG--LSGSPRL 210

  Fly   185 MAYCSKEAHSCVEKAAM--------ICFVKLRILEPDDDASLRGQTIYEAMEEDELQ----GLVP 237
            :.:.|.|.|..::|||.        :|||     |.|.    ||:.|.|.:|:...|    |..|
Human   211 ILFTSAECHYSMKKAASFLGIGTENVCFV-----ETDG----RGKMIPEELEKQVWQARKEGAAP 266

  Fly   238 FFVSTTLGTTGSCAFDNLPEIGKQLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTN 302
            |.|..|.|||...|||.|.||....:|. .:||||||::.|::.:..:.:.||.||..|||...|
Human   267 FLVCATSGTTVLGAFDPLDEIADICERH-SLWLHVDASWGGSALMSRKHRKLLHGIHRADSVAWN 330

  Fly   303 PNKWLLTNFDCSTLWVRDR---IRLTSALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWF 364
            |:|.|:....|..|.|:|:   ::...:.....|:.:..:.|.:.|.....:..|||..:.|.|.
Human   331 PHKMLMAGIQCCALLVKDKSDLLKKCYSAKASYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWM 395

  Fly   365 VLRSYGISGLQHYIRHHIKLAKRFEELVLKDKRFEICNQVKLGLVCFRLKGSDKLNEKLLSIINE 429
            ..::.|..||:..:...:.|::...:.:.|.:.|::..:.:...:||... ...|.|.      |
Human   396 TWKALGTLGLEERVNRALALSRYLVDEIKKREGFKLLMEPEYANICFWYI-PPSLREM------E 453

  Fly   430 SG-----KLHMVPASVGDRYI------------------IRFCAVAQNATAEDIDYAWDIIVDFA 471
            .|     ||::|..::.:|.:                  .|...::...:.||:|:..|.|
Human   454 EGPEFWAKLNLVAPAIKERMMKKGSLMLGYQPHRGKVNFFRQVVISPQVSREDMDFLLDEI---- 514

  Fly   472 NELLEKE 478
             :||.|:
Human   515 -DLLGKD 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	109/403 (27%)
GADL1	NP_997242.2	AAT_I	77..445	CDD:302748	109/403 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144949
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740