DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tdc2 and CG1486

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_608450.1	Gene:	CG1486 / 33108	FlyBaseID:	FBgn0031174	Length:	852	Species:	Drosophila melanogaster

Alignment Length:	830	Identity:	158/830 - (19%)
Similarity:	252/830 - (30%)	Gaps:	285/830 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DSTEFRKRGMEMVEY-------ICNYLETLNER---RVTPSVEP------GYLRHLLPPEAPQEP 50
            |..||....::.|.:       |..||..|:.:   |||.|:..      |.|.|...|.:....
  Fly   112 DDPEFPLPALDDVSHLALISHSIVAYLSHLDRQQLLRVTNSISGDATRWLGTLFHFAHPASSFHA 176

  Fly    51 EDWDQIMRDVEDKIMP--------GVTHWQHPRFH----------------------------AY 79
            ::.|.::|.|...|:.        |:.....|.|:                            .:
  Fly   177 DNADAVLRTVRLAIVARCPGYLEGGIPALAQPTFYISENTTPMRLHYACRQLGIPLEAIKVIPEH 241

  Fly    80 FPAGNSFPSILGDMLGDGIG----------CIGFS--------------------W-------AA 107
            ..:|....::|...:...:|          .||.|                    |       .|
  Fly   242 SQSGTMDVTLLQKQIQQDVGNNRTPLLVVADIGASLCGYVDNLLRLRDVCKAHNMWLHASGHGLA 306

  Fly   108 SPACTE--------LETIVLDWLGKAIGLPDHFLALKEGSTGGGVIQTSASECVLVTMLAARA-- 162
            :..|.:        |.::.|: ||..:|:|...:.|.........:....|:.:|...|.|.:
  Fly   307 ALVCAQNQGHVEEVLHSMALN-LGSWLGVPSLPIVLLHRPLQNSALSAFESDPILSRRLNALSLW 370

  Fly   163 ---QALKRLKAQHPFVEEGHLLSKLMAYCSKEAHSCVEKAAMICFVKLRILEPDDDASLRGQTIY 224
               |||.| ||   ..|..|:..:..:...:.|..|         ..:|:|.....|. .|.::.
  Fly   371 TSLQALGR-KA---IAERLHVAFQTCSILFEIASKC---------EGIRVLSHTPGAQ-TGASLS 421

  Fly   225 EAMEED-ELQGL---------VPFFVSTT--LGTTGSCAFDNLPEIGKQLQRFPGVWLHVDAAYA 277
            :.::.. ::|.|         ..|..|||  ||.:||.|                      ||.|
  Fly   422 DVIQSPFDVQALFDAAAPVVAYQFDGSTTIPLGGSGSSA----------------------AAAA 464

  Fly   278 GNSFICPELKPLLKGIEYADSFNTNPNKWL--LTNFDCSTLWVRDRIRLTSALVVDPLYLKHGYS 340
            ........||||.| |..|..|: ..|.||  :...||...              |...::|...
  Fly   465 AERETAEGLKPLEK-INNASYFD-RLNSWLGQILQRDCPNF--------------DFEVIEHPTH 513

  Fly   341 DAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQH--YIRHHIKLAKRFEELVLKDKRFEICNQ 403
            .:.|.|....:.|..:..|.:   .|.|:..|...|  .:|..||...||..||       .|:.
  Fly   514 GSCIRYCPLELGLGEQPPSSE---NLESFAQSLEAHVDILRATIKHKARFIHLV-------ECSD 568

  Fly   404 V----------KLGLVCFRLKG------------SDKLNEKLLSIINESGKLHMVPASVGDRYII 446
            |          .:|.|.|..:|            .:|||..|:..:..:.....:.........:
  Fly   569 VLRLVPLPEWAGMGGVRFVPEGWESLLTDQAKTELNKLNIDLVEALKSTDNAFSLGEGTDGLICV 633

  Fly   447 RFCAVAQNATAEDIDYAWDIIVDFANELLEKEQ-HDELSEI-----------MNRKKQDTLAQK- 498
            ||..|......|::   .|::|.....:.|..: .|.:|||           :.|:.::.|.|:
  Fly   634 RFGMVTHETEVEEL---LDLVVTVGKSVQENSRVLDTMSEIVKKGIEAVTADLQRESEEKLWQEG 695

  Fly   499 --------------------------RSFFVR---MVSDPKIYN-------------PAINKAGT 521
                                      ||..:.   :.|...||.             ||.....|
  Fly   696 ILRHVPVVGRVFNWWSPPAKESGIKGRSLNLTQGVVESTENIYKYHMQMTGATAHQLPANRSPPT 760

  Fly   522 PKLSMELPSPVVSRGSAPIIRTQSSVDHNSWISWPLAFLFNSNNEEKGSNVSLRFRHLDTNVRPS 586
            |.:.    :|||:....|:..|...|..|.          |.:...:|:.|       .:.....
  Fly   761 PMVQ----TPVVAPALPPVFPTVEPVPGNG----------NGSGASEGTPV-------QSGEASG 804

  Fly   587 SSRRNSGAGSSPSP-ENELDYVNVQQQQMEQRSPRRSPMAVRKASSTRDN 635
            |....|||..|.:| :|.:|:.....|.....|  ..|..|..:|:..:|
  Fly   805 SMPAASGAAPSAAPTQNHVDHARTVSQSSAASS--TVPELVAASSAINNN 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	94/496 (19%)
CG1486	NP_608450.1	AAT_I	159..>384	CDD:302748	37/229 (16%)
CG1486	NP_608450.1	WWbp	<725..801	CDD:304964	17/96 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445354
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840