DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc2 and GAD1

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_000808.2	Gene:	GAD1 / 2571	HGNCID:	4092	Length:	594	Species:	Homo sapiens

Alignment Length:	503	Identity:	119/503 - (23%)
Similarity:	215/503 - (42%)	Gaps:	65/503 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MEMVEYICNYLETLNERRVTPSVEPGYLRHLLPP------EAPQEPEDWDQIMRDVEDKIMPGVT 69
            :|:|:.:.||:....:|. |..::..:...||..      |....||..:||:.|..|.:..||
Human   118 LEVVDILLNYVRKTFDRS-TKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGV- 180

  Fly    70 HWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPDHFLA 134
            ...||||......|.....:.|:.|........|::..:|....:|.|.|..:.:.:|.
Human   181 RTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGW------ 239

  Fly   135 LKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHLLSKLMAYCSKEAHSCVEKA 199
              ....|.|:.....:...:.:::|||.:....:|.:....     :.||:.:.|:::|..::||
Human   240 --SSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAA-----VPKLVLFTSEQSHYSIKKA 297

  Fly   200 A------------MICFVKLRILEPDDDASLRGQTIYEAMEEDELQGLVPFFVSTTLGTTGSCAF 252
            .            :.|..:.:|:..|.:|.     |.||.:    :|.|||:|:.|.|||...||
Human   298 GAALGFGTDNVILIKCNERGKIIPADFEAK-----ILEAKQ----KGYVPFYVNATAGTTVYGAF 353

  Fly   253 DNLPEIGKQLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLW 317
            |.:.||....::: .:|||||||:.|...:..:.:..|.|||.|:|...||:|.:.....||.:.
Human   354 DPIQEIADICEKY-NLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAIL 417

  Fly   318 VRDR--IRLTSALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRH 380
            |:::  ::..:.:....|:......|.:.|.....:...|.....|.|.:.::.|..|.::.|..
Human   418 VKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINK 482

  Fly   381 HIKLAKRFEELVLKDKRFEIC--NQVKLGLVCF-----RLKG-------SDKLNE---KLLSIIN 428
            .::||:.....:...:.||:.  .:.:...|||     .|:|       .:||::   |:.:::.
Human   483 CLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMM 547

  Fly   429 ESGKLHMVPASVGDRYIIRFCAVAQN--ATAEDIDYAWDIIVDFANEL 474
            |||...:.....||:... |..|..|  ||..|||:..:.|.....:|
Human   548 ESGTTMVGYQPQGDKANF-FRMVISNPAATQSDIDFLIEEIERLGQDL 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	93/405 (23%)
GAD1	NP_000808.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Pyridoxal_deC	144..518	CDD:365998	93/397 (23%)
		Substrate binding	190..192		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144951
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740