DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tdc2 and Hdc

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_058712.2	Gene:	Hdc / 24443	RGDID:	2790	Length:	656	Species:	Rattus norvegicus

Alignment Length:	645	Identity:	287/645 - (44%)
Similarity:	393/645 - (60%)	Gaps:	72/645 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSTEFRK---RGMEMVEYICNYLETLNERRVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRDVED 62
            |:.:|:|:   ||.|||:|||.||.||.||:|||:|:|||||..:|..||:||:.||.|..|:|.
  Rat     2 MEPSEYREYQARGKEMVDYICQYLSTLRERQVTPNVKPGYLRAQIPSSAPEEPDSWDSIFGDIEQ 66

  Fly    63 KIMPGVTHWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIG 127
            .|||||.|||.|..|||:||..|:||:|||||.|.|.|:||:||:||||||||..::|||.|.:|
  Rat    67 IIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNIMDWLAKMLG 131

  Fly   128 LPDHFLALKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHLLSKLMAYCSKEA 192
            |||.||.....|.||||:|::.||..|:.:||||...:..:||..|..:|..|.::|:||.|.:|
  Rat   132 LPDFFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKAHEPNADESSLNARLVAYASDQA 196

  Fly   193 HSCVEKAAMICFVKLRILEPDDDASLRGQTIYEAMEEDELQGLVPFFVSTTLGTTGSCAFDNLPE 257
            ||.||||.:|..||::.|..||:.||||:.:.:|:|||:.|||||.||..||||||.||||.|.|
  Rat   197 HSSVEKAGLISLVKIKFLPVDDNFSLRGEALQKAIEEDKQQGLVPVFVCATLGTTGVCAFDKLSE 261

  Fly   258 IGKQLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWVRDRI 322
            :|....| .|:||||||||||.:|:||||:..||||||||||..||:||::.:|||:..||:|:.
  Rat   262 LGPICAR-EGLWLHVDAAYAGTAFLCPELRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKY 325

  Fly   323 RLTSALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRHHIKLAKR 387
            :|.....|:|:||:|..|..|.|:.||.:||||||||:|||||:||:|:..||.::||...:||.
  Rat   326 KLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTDMAKY 390

  Fly   388 FEELVLKDKRFEICNQVKLGLVCFRLKGSDKLNEKLLSIINESGKLHMVPASVGDRYIIRFCAVA 452
            ||.||..|..|||..:..||||.|||||.:.|.|.:|..|.::|::.::||::.|:.||||...:
  Rat   391 FESLVRSDPVFEIPAERHLGLVVFRLKGPNCLTESVLKEIAKTGQVFLIPATIQDKLIIRFTVTS 455

  Fly   453 QNATAEDIDYAWDIIVDFANELLEKEQHDELSEIMNRKKQDTLAQKRSFFVRMVSDPKIYNPAIN 517
            |..|.:||...|::|.:.||.:|  .||                        ..|.|
  Rat   456 QFTTKDDILRDWNLIREAANLVL--SQH------------------------CTSQP-------- 486

  Fly   518 KAGTPKLSMELPSPVVSRGSAPIIRTQSSVDHNSWISWPLAFLFNSNNEEKGSNVSLR--FR--- 577
               :|:....:|.||          |:.|.|..:.:|      ..|.||.....|.:|  ||
  Rat   487 ---SPRAKNLIPPPV----------TRDSKDLTNGLS------LESVNEGGDDPVQVRKIFRLPG 532

  Fly   578 -HLDTNVRPSSSRRNSGAGSSPSPENEL-----DYVNVQQQQ--MEQRSPRRSPMAVRKA 629
             .|:|.:.|.....:..|  |.:.:::|     .|::||.::  |...|....||:.:|:
  Rat   533 DSLETTMDPFDDCFSEEA--SDTTKHKLSSFLFSYLSVQNKKKTMRSLSCNSMPMSAQKS 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	209/378 (55%)
Hdc	NP_058712.2	Pyridoxal_deC	39..417	CDD:278699	209/378 (55%)
Hdc	NP_058712.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..502		8/65 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830