DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tdc2 and Gad1

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_058703.1	Gene:	Gad1 / 24379	RGDID:	2652	Length:	593	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	118/503 - (23%)
Similarity:	212/503 - (42%)	Gaps:	65/503 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MEMVEYICNYLETLNERRVTPSVEPGYLRHLLPP------EAPQEPEDWDQIMRDVEDKIMPGVT 69
            :|:|:.:.||:....:|. |..::..:...||..      |....||..:||:.|..|.:..||
  Rat   117 LEVVDILLNYVRKTFDRS-TKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGV- 179

  Fly    70 HWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPDHFLA 134
            ...||||......|.....:.|:.|........|::..:|....:|.|.|..:.:.||.
  Rat   180 RTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIIGW------ 238

  Fly   135 LKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHLLSKLMAYCSKEAHSCVEKA 199
              ....|.|:.....:...:.:::|||.:....:|.:....     :.||:.:.|:.:|..::||
  Rat   239 --SNKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAA-----VPKLVLFTSEHSHYSIKKA 296

  Fly   200 A------------MICFVKLRILEPDDDASLRGQTIYEAMEEDELQGLVPFFVSTTLGTTGSCAF 252
            .            :.|..:.:|:..|.:|.     |.:|.:    :|.||.:|:.|.|||...||
  Rat   297 GAALGFGTDNVILIKCNERGKIIPADLEAK-----ILDAKQ----KGFVPLYVNATAGTTVYGAF 352

  Fly   253 DNLPEIGKQLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLW 317
            |.:.||....::: .:|||||||:.|...:..:.:..|.|||.|:|...||:|.:.....||.:.
  Rat   353 DPIQEIADICEKY-NLWLHVDAAWGGGLLMSRKHRHKLSGIERANSVTWNPHKMMGVLLQCSAIL 416

  Fly   318 VRDR--IRLTSALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRH 380
            |:::  ::..:.:....|:......|.:.|.....:...|.....|.|.:.::.|..|.::.|..
  Rat   417 VKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINK 481

  Fly   381 HIKLAKRFEELVLKDKRFEIC--NQVKLGLVCF-----RLKG-------SDKLNE---KLLSIIN 428
            .::||:.....:...:.||:.  .:.:...|||     .|:|       .:||:.   |:.:::.
  Rat   482 CLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPERREKLHRVAPKIKALMM 546

  Fly   429 ESGKLHMVPASVGDRYIIRFCAVAQN--ATAEDIDYAWDIIVDFANEL 474
            |||...:.....||:... |..|..|  ||..|||:..:.|.....:|
  Rat   547 ESGTTMVGYQPQGDKANF-FRMVISNPAATQSDIDFLIEEIERLGQDL 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	92/405 (23%)
Gad1	NP_058703.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Pyridoxal_deC	143..517	CDD:395219	92/397 (23%)
		Substrate binding. /evidence=ECO:0000250	189..191		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338646
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740