Protein Alignment Tdc2 and Sepsecs

DIOPT Version :10

• Sequence 1: NP_724489.1
• Gene: Tdc2 / 246620
• FlyBaseID: FBgn0050446
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: NP_766078.1
• Gene: Sepsecs / 211006
• MGIID: 1098791
• Length: 504
• Species: Mus musculus
• Alignment Length: 549
• Identity: 111/549 - (20%)
• Similarity: 179/549 - (32%)
• Gaps: 188/549 - (34%)

  Fly    26 ERRVTPSVEPGYLR----------HL--LPPEAPQEPED-WDQIMRDV----------------- 60
            ||||:|:    |:|          ||  |..|..:.||| ||:...::
Mouse    10 ERRVSPA----YVRQGCEARRAHEHLIRLLLEQGKCPEDGWDESTLELFLHELAVMDSNNFLGNC 70

  Fly    61 -----EDKIMPGVTHWQHPRF-HAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVL 119
                 |.::...:...:|.|| |                   |||..|...|..|
Mouse    71 GVGEREGRVASALVARRHYRFIH-------------------GIGRSGDISAVQP---------- 106

  Fly   120 DWLGKAIGLPDHFLALKEGSTGGGVIQT-------SASECVLVTMLAARAQALKRLKAQHPFVEE 177
                ||.|     .:|....|...|:..       |.:.|.:|.|....:..|..|..:|...:
Mouse   107 ----KAAG-----SSLLNKITNSLVLNVIKLAGVHSVASCFVVPMATGMSLTLCFLTLRHKRPK- 161

  Fly   178 GHLLSKLMAYCSKEAHSCVEKAAMICF---VKLRILEPDDDASLRGQTIYEAMEEDELQGLVPFF 239
                :|.:.:...:..||.:......|   |...:||.|:   ||  |..:|:|. ::|.|.|..
Mouse   162 ----AKYIIWPRIDQKSCFKSMVTAGFEPVVIENVLEGDE---LR--TDLKAVEA-KIQELGPEH 216

  Fly   240 VSTTLGTTGSCAFDNLPEIGKQLQRFPGVWLHVDA------AYAGNSFICPELKPLLKGIEYADS 298
            :.....||...|    |.:..:|:....:..:.|.      ||...|..|..|......:...|:
Mouse   217 ILCLHSTTACFA----PRVPDRLEELAVICANYDIPHVVNNAYGLQSSKCMHLIQQGARVGRIDA 277

  Fly   299 FNTNPNKWLLTNFDCSTLWVRDRIRLTSALVVDPLYLKHGYSDAAIDYRHWGVPLSRRF------ 357
            |..:.:|    ||         .:.:..|::.       |:::..|.      .:|:.:
Mouse   278 FVQSLDK----NF---------MVPVGGAIIA-------GFNEPFIQ------DISKMYPGRASA 316

  Fly   358 -RSLKLWFVLRSYGISGLQHYIRHH-----------IKLAKRFEELVLKDKRFEICNQVKLGLVC 410
             .||.:...|.|.|.||.:..::..           .|||:...|.:|:...    |.:.|.:..
Mouse   317 SPSLDVLITLLSLGCSGYRKLLKERKEMFVYLSTQLKKLAEAHNERLLQTPH----NPISLAMTL 377

  Fly   411 FRLKG-SDKLNEKLLSII--NESGKLHMVP---------------ASVGDRYIIRFCAVAQNATA 457
            ..:.| .||...:|.|::  .:......||               .|..|.|.   ||....|.|
Mouse   378 KTIDGHHDKAVTQLGSMLFTRQVSGARAVPLGNVQTVSGHTFRGFMSHADNYP---CAYLNAAAA 439

  Fly   458 -----EDIDYAWDII--VDFANELLEKEQ 479
                 :|:|.   .|  :|....::.|||
Mouse   440 IGMKMQDVDL---FIKRLDKCLNIVRKEQ 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:395219	85/448 (19%)
Sepsecs	NP_766078.1	Tetramerization. /evidence=ECO:0000269|PubMed:18093968	1..44		12/37 (32%)
		selenium_SpcS	13..458	CDD:211833	105/537 (20%)
		Phosphate loop (P-loop). /evidence=ECO:0000269|PubMed:18093968	96..106		3/9 (33%)