Protein Alignment Tdc2 and tdc-1

DIOPT Version :9

• Sequence 1: NP_724489.1
• Gene: Tdc2 / 246620
• FlyBaseID: FBgn0050446
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: NP_495743.1
• Gene: tdc-1 / 174327
• WormBaseID: WBGene00006562
• Length: 705
• Species: Caenorhabditis elegans
• Alignment Length: 583
• Identity: 336/583 - (57%)
• Similarity: 412/583 - (70%)
• Gaps: 59/583 - (10%)

  Fly     1 MDSTEFRKRGMEMVEYICNYLETLNERRVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRDVEDKIM 65
            |...|||:.|.|.|:||.:|||.:.:|||.|::|||||:.|:|.|||..||.::.:|.|.|..||
 Worm    77 MTRDEFRQYGKETVDYIVDYLENIQKRRVVPAIEPGYLKDLIPSEAPNTPESFESVMEDFEKLIM 141

  Fly    66 PGVTHWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPD 130
            ||:|||||||||||||||||||||:.|||.|.|||:||||||.||.||||.|:|||.||.||||.
 Worm   142 PGITHWQHPRFHAYFPAGNSFPSIIADMLSDAIGCVGFSWAACPAMTELELIMLDWFGKMIGLPA 206

  Fly   131 HFLALKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHLLSKLMAYCSKEAHSC 195
            .||.|.|...||||||:|||||..||:||||.:.:|.|:.:.||||||.|||||:|||||||||.
 Worm   207 EFLPLTENGKGGGVIQSSASECNFVTLLAARFEVMKELRQRFPFVEEGLLLSKLIAYCSKEAHSS 271

  Fly   196 VEKAAMICFVKLRILEPDDDASLRGQTIYEAMEEDELQGLVPFFVSTTLGTTGSCAFDNLPEIG- 259
            ||||.||..|||||||.|....|||.|:..|::||...||:|||||||||||..|:||.|.|||
 Worm   272 VEKACMIGMVKLRILETDSKFRLRGDTLRNAIQEDRNLGLIPFFVSTTLGTTSCCSFDVLSEIGP 336

  Fly   260 --KQLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWVRDRI 322
              |:.:    :||||||||:|::|||||.:||:.|||||.|||||||||||.||||||:|||||.
 Worm   337 ICKENE----LWLHVDAAYSGSAFICPEFRPLMNGIEYAMSFNTNPNKWLLINFDCSTMWVRDRF 397

  Fly   323 RLTSALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRHHIKLAKR 387
            :||.|||||||||:|.:.|.:|||||||:||||||||||||||:|.|||.|||.|||.|::|||:
 Worm   398 KLTQALVVDPLYLQHSWMDKSIDYRHWGIPLSRRFRSLKLWFVIRMYGIDGLQKYIREHVRLAKK 462

  Fly   388 FEELVLKDKRFEICNQVKLGLVCFRLKGSDKLNEKLLSIINESGKLHMVPASVGDRYIIRFCAVA 452
            .|.|:..|.:|||.|:|.:||||||:||.|:||:.||:.:|.||::||||||:|||::||||..|
 Worm   463 METLLRADAKFEIVNEVIMGLVCFRMKGDDELNQTLLTRLNASGRIHMVPASLGDRFVIRFCVCA 527

  Fly   453 QNATAEDIDYAWDIIVDFANELLE-------KEQHDEL--------------------------- 483
            :|||.:||:.|::||......:|.       .|:.:|.
 Worm   528 ENATDKDIEVAYEIIAQATQHVLHDSVKAVIAEEDEEAVALEEMVADLNITETPEKCLTRQNSAN 592

  Fly   484 --------------SEIMNRKKQDTLAQKRSFFVRMVSDPKIYNPAI----NKAGTPKLSMEL 528
                          .||:.:|:.::||:||||.||||||||.|||.|    |.|...|:|.:|
 Worm   593 AAESGQKLERQLSKEEILAQKQHESLAKKRSFLVRMVSDPKCYNPKIVRHLNMANHRKMSQDL 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	258/381 (68%)
tdc-1	NP_495743.1	Pyridoxal_deC	111..489	CDD:278699	258/381 (68%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158343
Domainoid	1	1.000	544	1.000	Domainoid score	I128
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H76115
Inparanoid	1	1.050	667	1.000	Inparanoid score	I387
Isobase	1	0.950	-	0.815392	Normalized mean entropy	S2516
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	1	1.000	-	-		oto19882
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	1	1.100	-	-	LDO	PTHR11999
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3838
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890