Protein Alignment Tdc2 and tdc-1

DIOPT Version :10

• Sequence 1: NP_724489.1
• Gene: Tdc2 / 246620
• FlyBaseID: FBgn0050446
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: NP_495743.1
• Gene: tdc-1 / 174327
• WormBaseID: WBGene00006562
• Length: 705
• Species: Caenorhabditis elegans
• Alignment Length: 583
• Identity: 336/583 - (57%)
• Similarity: 412/583 - (70%)
• Gaps: 59/583 - (10%)

  Fly     1 MDSTEFRKRGMEMVEYICNYLETLNERRVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRDVEDKIM 65
            |...|||:.|.|.|:||.:|||.:.:|||.|::|||||:.|:|.|||..||.::.:|.|.|..||
 Worm    77 MTRDEFRQYGKETVDYIVDYLENIQKRRVVPAIEPGYLKDLIPSEAPNTPESFESVMEDFEKLIM 141

  Fly    66 PGVTHWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPD 130
            ||:|||||||||||||||||||||:.|||.|.|||:||||||.||.||||.|:|||.||.||||.
 Worm   142 PGITHWQHPRFHAYFPAGNSFPSIIADMLSDAIGCVGFSWAACPAMTELELIMLDWFGKMIGLPA 206

  Fly   131 HFLALKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHLLSKLMAYCSKEAHSC 195
            .||.|.|...||||||:|||||..||:||||.:.:|.|:.:.||||||.|||||:|||||||||.
 Worm   207 EFLPLTENGKGGGVIQSSASECNFVTLLAARFEVMKELRQRFPFVEEGLLLSKLIAYCSKEAHSS 271

  Fly   196 VEKAAMICFVKLRILEPDDDASLRGQTIYEAMEEDELQGLVPFFVSTTLGTTGSCAFDNLPEIG- 259
            ||||.||..|||||||.|....|||.|:..|::||...||:|||||||||||..|:||.|.|||
 Worm   272 VEKACMIGMVKLRILETDSKFRLRGDTLRNAIQEDRNLGLIPFFVSTTLGTTSCCSFDVLSEIGP 336

  Fly   260 --KQLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWVRDRI 322
              |:.:    :||||||||:|::|||||.:||:.|||||.|||||||||||.||||||:|||||.
 Worm   337 ICKENE----LWLHVDAAYSGSAFICPEFRPLMNGIEYAMSFNTNPNKWLLINFDCSTMWVRDRF 397

  Fly   323 RLTSALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRHHIKLAKR 387
            :||.|||||||||:|.:.|.:|||||||:||||||||||||||:|.|||.|||.|||.|::|||:
 Worm   398 KLTQALVVDPLYLQHSWMDKSIDYRHWGIPLSRRFRSLKLWFVIRMYGIDGLQKYIREHVRLAKK 462

  Fly   388 FEELVLKDKRFEICNQVKLGLVCFRLKGSDKLNEKLLSIINESGKLHMVPASVGDRYIIRFCAVA 452
            .|.|:..|.:|||.|:|.:||||||:||.|:||:.||:.:|.||::||||||:|||::||||..|
 Worm   463 METLLRADAKFEIVNEVIMGLVCFRMKGDDELNQTLLTRLNASGRIHMVPASLGDRFVIRFCVCA 527

  Fly   453 QNATAEDIDYAWDIIVDFANELLE-------KEQHDEL--------------------------- 483
            :|||.:||:.|::||......:|.       .|:.:|.
 Worm   528 ENATDKDIEVAYEIIAQATQHVLHDSVKAVIAEEDEEAVALEEMVADLNITETPEKCLTRQNSAN 592

  Fly   484 --------------SEIMNRKKQDTLAQKRSFFVRMVSDPKIYNPAI----NKAGTPKLSMEL 528
                          .||:.:|:.::||:||||.||||||||.|||.|    |.|...|:|.:|
 Worm   593 AAESGQKLERQLSKEEILAQKQHESLAKKRSFLVRMVSDPKCYNPKIVRHLNMANHRKMSQDL 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:395219	258/381 (68%)
tdc-1	NP_495743.1	Pyridoxal_deC	111..489	CDD:395219	258/381 (68%)