DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tdc2 and DDC

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	NP_000781.2	Gene:	DDC / 1644	HGNCID:	2719	Length:	480	Species:	Homo sapiens

Alignment Length:	481	Identity:	260/481 - (54%)
Similarity:	347/481 - (72%)	Gaps:	4/481 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSTEFRKRGMEMVEYICNYLETLNERRVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRDVEDKIM 65
            |:::|||:||.|||:|:.||:|.:..|:|.|.|||||||.|:|..|||||:.::.|:.|||..||
Human     1 MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIM 65

  Fly    66 PGVTHWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPD 130
            ||||||..|.|.||||..:|:|::|.|||...|||||||||||||||||||:::|||||.:.||.
Human    66 PGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELPK 130

  Fly   131 HFLALKEGSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGHLLSKLMAYCSKEAHSC 195
            .||..|.|. ||||||.||||..||.:||||.:.:.||:|..|.:.:..::.||:||.|.:|||.
Human   131 AFLNEKAGE-GGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSS 194

  Fly   196 VEKAAMICFVKLRILEPDDDASLRGQTIYEAMEEDELQGLVPFFVSTTLGTTGSCAFDNLPEIGK 260
            ||:|.:|..|||:.:..|.:.::|...:.||:|.|:..||:|||:..|||||..|:||||.|:|.
Human   195 VERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGP 259

  Fly   261 QLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWVRDRIRLT 325
            ...: ..:||||||||||::|||||.:.||.|:|:|||||.||:||||.|||||.:||:.|..||
Human   260 ICNK-EDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLT 323

  Fly   326 SALVVDPLYLKHGYSDAAI--DYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRHHIKLAKRF 388
            .|..:||.||||.:.|:.:  |||||.:||.|||||||:|||.|.||:.|||.|||.|::|:..|
Human   324 GAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEF 388

  Fly   389 EELVLKDKRFEICNQVKLGLVCFRLKGSDKLNEKLLSIINESGKLHMVPASVGDRYIIRFCAVAQ 453
            |.||.:|.|||||.:|.|||||||||||:|:||.||..||.:.|:|:||..:.|::::||...::
Human   389 ESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSR 453

  Fly   454 NATAEDIDYAWDIIVDFANELLEKEQ 479
            ...:..:..||:.|.:.|.::|..|:
Human   454 TVESAHVQRAWEHIKELAADVLRAER 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	218/380 (57%)
DDC	NP_000781.2	Pyridoxal_deC	35..414	CDD:365998	218/380 (57%)
DDC	NP_000781.2	2 X approximate tandem repeats	58..178		73/120 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.815392	Normalized mean entropy	S2516
OMA	1	1.010	-	-		QHG57772
OrthoDB	1	1.010	-	-		D223497at33208
OrthoFinder	1	1.000	-	-		FOG0000865
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100572
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3838
SonicParanoid	1	1.000	-	-		X696
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.710