DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tdc2 and gad1a

DIOPT Version :9

Sequence 1:	NP_724489.1	Gene:	Tdc2 / 246620	FlyBaseID:	FBgn0050446	Length:	637	Species:	Drosophila melanogaster
Sequence 2:	XP_002663350.1	Gene:	gad1a / 100329827	ZFINID:	ZDB-GENE-070912-472	Length:	591	Species:	Danio rerio

Alignment Length:	505	Identity:	125/505 - (24%)
Similarity:	216/505 - (42%)	Gaps:	69/505 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MEMVEYICNYLETLNERRVTPSVEPGYLRHLLPP------EAPQEPEDWDQIMRDVEDKIMPGVT 69
            :|:||.:.||:....:|. |..::..:...||..      |...:||..:||:.|..|.:..||
Zfish   115 LEVVEILTNYVRKTFDRS-TKVLDFHHPHQLLEGMEGFNLELCDQPESLEQILVDCRDTLKYGV- 177

  Fly    70 HWQHPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPDHFLA 134
            ...||||.....:|.....:.|:.|........|::..:|....:|.:.|..:.:.:|.|:
Zfish   178 RTGHPRFFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTLKKMREIVGWPN---- 238

  Fly   135 LKEGSTGGGVIQTSASECVLVTMLAARAQALKRLK----AQHPFVEEGHLLSKLMAYCSKEAHSC 195
                ..|.|:.....:...:.:::.||.:....:|    |..|         :|:.:.|:.:|..
Zfish   239 ----GEGDGIFSPGGAISNMYSVMVARYKHYPEIKIKGMAAAP---------RLVLFTSEHSHYS 290

  Fly   196 VEKA-AMICF--VKLRILEPDDDASLRGQTIYEAME----EDELQGLVPFFVSTTLGTTGSCAFD 253
            ::|| |::.|  ..|.:|..|:    ||:.|...:|    :.:.:|.||.||:.|.|:|...|||
Zfish   291 IKKASAVLGFGTENLILLRTDE----RGRVIPADLEAKVIDAKQKGFVPMFVNATAGSTVYGAFD 351

  Fly   254 NLPEIGKQLQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWV 318
            .:.||....::: .:|||||.|:.|...:..:.|..|.|||.|:|...||:|.:.....||.:.|
Zfish   352 PINEIADICEKY-NMWLHVDGAWGGGLLMSRKHKHKLSGIERANSVTWNPHKMMGVPLQCSAILV 415

  Fly   319 RDR--IRLTSALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRHH 381
            |::  ::..:::....|:......|...|.....:...|.....|.|.:.:|.|.:|.:.:|...
Zfish   416 REKGLLQGCNSMCAGYLFQPDKQYDVTYDTGDKAIQCGRHVDIFKFWLMWKSKGTTGFEKHIDRC 480

  Fly   382 IKLAKRFEELVLKDKRFEICNQVKLG-----LVCF-------RL--KGSDKLNE------KLLSI 426
            ::|:   |.|..|.|..|....|..|     .|||       ||  .|.:|.:.      |:.::
Zfish   481 LELS---EYLYHKIKNREGYEMVFQGEPQHTNVCFWYIPPSLRLLPDGEEKRHRLHKVAPKIKAL 542

  Fly   427 INESGKLHMVPASVGDRYIIRFCAVAQN--ATAEDIDYAWDIIVDFANEL 474
            :.|.|...:.....|:: :..|..|..|  .|..|||:..|.|.....:|
Zfish   543 MMECGTTMVGYQPQGEK-VNFFRMVVSNPAVTRSDIDFLIDEIERLGQDL 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:278699	102/411 (25%)
gad1a	XP_002663350.1	Pyridoxal_deC	141..515	CDD:278699	100/399 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578196
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840