Protein Alignment Tdc2 and gad3

DIOPT Version :10

• Sequence 1: NP_724489.1
• Gene: Tdc2 / 246620
• FlyBaseID: FBgn0050446
• Length: 637
• Species: Drosophila melanogaster
• Sequence 2: NP_001083039.2
• Gene: gad3 / 100038790
• ZFINID: ZDB-GENE-070424-80
• Length: 546
• Species: Danio rerio
• Alignment Length: 511
• Identity: 126/511 - (24%)
• Similarity: 215/511 - (42%)
• Gaps: 93/511 - (18%)

  Fly     8 KRGMEMVEYICNYLETLNERRVTPSVEPGYLRHLLPPEAPQEPEDWDQIMRDVEDKIMPGVTHWQ 72
            ||..:::::  :|...|||     .:|...|      |.|.:|::.:|::.|..|.:..|| ...
Zfish    85 KRSTKVLDF--HYPHQLNE-----GLEGFSL------ELPDQPDNLEQLLVDCRDTLKYGV-KTG 135

  Fly    73 HPRFHAYFPAGNSFPSILGDMLGDGIGCIGFSWAASPACTELETIVLDWLGKAIGLPDHFLALKE 137
            ||||......|.....:.|:.|........|::..||....:|.:||..:...||.|:
Zfish   136 HPRFFNQLSTGLDIVGLAGEWLTSTANTNMFTYEISPVFILMEEVVLRKMHTIIGWPE------- 193

  Fly   138 GSTGGGVIQTSASECVLVTMLAARAQALKRLKAQHPFVEEGH---LLSKLMAYCSKEAHSCVEKA 199
             ..|.|:.....|...|.::|.||......:|.        |   .:.:|..:.|..:|..::|:
Zfish   194 -EDGDGIFCPGGSMSNLYSVLLARFHLFPAVKT--------HGMCAIPRLAMFTSAHSHYSIKKS 249

  Fly   200 AMICFV---KLRILEPDDDASLRGQTIYEAMEEDELQGLVPFFVSTTLGTTGSCAFDNLPEIGKQ 261
            |.:..:   .:.::..|:...:....:..::||.:.:|||||:|:.|.|||...|||.|.:|. .
Zfish   250 AAVLGIGTENVIVVRCDERGKMISSELNSSIEEAKSKGLVPFYVNATAGTTVYGAFDPLHKIA-D 313

  Fly   262 LQRFPGVWLHVDAAYAGNSFICPELKPLLKGIEYADSFNTNPNKWLLTNFDCSTLWVRDR--IRL 324
            :....|:|:|||||:.|...:..:.:..|.|||.|.|...||:|.:.....|||:.|:.:  ::.
Zfish   314 ICEHHGLWMHVDAAWGGGLLLSNKHRVKLHGIERAHSVTWNPHKMMGVPLQCSTILVKRKGLLQQ 378

  Fly   325 TSALVVDPLYLKHGYSDAAIDYRHWGVPLSRRFRSLKLWFVLRSYGISGLQHYIRH--------H 381
            .:.|..:.|:....:.:.:.|.....:...|.....|||.:.::.|..|.:..:.|        :
Zfish   379 CNQLCAEYLFQPDKHYEVSYDTGDKSIQCGRHVDIFKLWLMWKAKGSEGFESQVNHCLENAEYLY 443

  Fly   382 IKLAKRFE-ELVLKDKRFEICNQVKLGLVCF-----RLK----GSDKLNEKLLSIINESGKLHMV 436
            .||.:|.: :||.|.|. |..|      |||     |::    |.::..|           ||||
Zfish   444 YKLKRRTDFQLVFKGKP-EHSN------VCFWYLPKRVQNIPLGPEREKE-----------LHMV 490

  Fly   437 PASVGDRYI---------------IRF--CAVAQNAT-AEDIDYAWDIIVDFANEL 474
            ...:..:.:               :.|  |..:..|| .||:|:..|.||....||
Zfish   491 APKIKTKMMEEGFTMIGYQPLEDKVNFFRCVFSNPATQREDVDFLLDEIVRLGCEL 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tdc2	NP_724489.1	Pyridoxal_deC	35..414	CDD:395219	101/400 (25%)
gad3	NP_001083039.2	Pyridoxal_deC	96..469	CDD:395219	104/408 (25%)