DRSC/TRiP Functional Genomics Resources

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Protein Alignment Opbp and ZXDA

DIOPT Version :9

Sequence 1:NP_724479.1 Gene:Opbp / 246618 FlyBaseID:FBgn0050443 Length:562 Species:Drosophila melanogaster
Sequence 2:NP_009087.1 Gene:ZXDA / 7789 HGNCID:13198 Length:799 Species:Homo sapiens


Alignment Length:466 Identity:110/466 - (23%)
Similarity:179/466 - (38%) Gaps:109/466 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   137 CPRAESG---GSSQQDGDAKAPVRRKLASVSARTGPRDASSVISCG-----------ICNTVFSS 187
            ||...|.   ....:...|.|| :.:...::|..|||   .::..|           :|...|:.
Human   220 CPELRSDLLLAEPAEPAPAPAP-QEEAEGLAAALGPR---GLLGSGPGVVLYLCPEALCGQTFAK 280

  Fly   188 EKFLKFHMRIH---ENRAPKSIQDALPIGA-------------H-QQYSELDQFYC--EICNKSF 233
            :..||.|:..|   :.:.|..    .|:|.             | |.:.:|..|.|  |.|.|||
Human   281 KHQLKMHLLTHSSSQGQRPFK----CPLGGCGWTFTTSYKLKRHLQSHDKLRPFGCPAEGCGKSF 341

  Fly   234 DETL-LTVHKQMHQQESSEIMCSICNRKFENEVTYQMHQKIHEKPRDSESSRKLAQRTSLDKEKP 297
            .... |..|.:.|:||:| ..|.:|...|..:.....||:.|.:|                 |:|
Human   342 TTVYNLKAHMKGHEQENS-FKCEVCEESFPTQAKLGAHQRSHFEP-----------------ERP 388

  Fly   298 GFPCQY--CERVFTRPFEKVKHERVHTGEKP-YACEV--CGKTFRVSYSLTLHLRTHTNIRPYVC 357
             :.|.:  |::.|........|.|.|..|:. ::|..  |.|.:..:..|.:|||:||..||::|
Human   389 -YQCAFSGCKKTFITVSALFSHNRAHFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGERPFLC 452

  Fly   358 TV--CNKRFKSHQVYSHHLRIHSSERQFSC--DACPKTFRTSVQLYAHKNTH--TKPYRCAV--C 414
            ..  |...|.|......|.|.|..:|:|.|  :.|.|:|..:..|..|..||  |||:.|.|  |
Human   453 DFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITHLGTKPFVCPVAGC 517

  Fly   415 NRPFSSMYAVKNHMQTHKEISSKGSVGSGTPNIKSAATSKSQAAGKFYCNTCGAEYARLFALRLH 479
            ...||:..::..|.:.|               ::...|.||:..    .::|...:....:::.|
Human   518 CARFSARSSLYIHSKKH---------------LQDVDTWKSRCP----ISSCNKLFTSKHSMKTH 563

  Fly   480 MKSAH----GLVEEQE-----NPATSTDAAHVAETDDSETAVLI-------AAAEADAAYINAVV 528
            |...|    .|:.:.|     .|::...:....:..|:|...|.       :||..|.|.:|:.:
Human   564 MVKRHKVGQDLLAQLEAANSLTPSSELTSQRQNDLSDAEIVSLFSDVPDSTSAALLDTALVNSGI 628

  Fly   529 NDVDIVGTVPT 539
            ..:|:.....|
Human   629 LTIDVASVSST 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OpbpNP_724479.1 C2H2 Zn finger 254..274 CDD:275368 5/19 (26%)
C2H2 Zn finger 301..321 CDD:275368 5/21 (24%)
zf-H2C2_2 316..336 CDD:290200 7/22 (32%)
C2H2 Zn finger 329..349 CDD:275368 7/21 (33%)
zf-H2C2_2 341..366 CDD:290200 11/26 (42%)
C2H2 Zn finger 357..377 CDD:275368 6/21 (29%)
C2H2 Zn finger 385..405 CDD:275368 6/21 (29%)
C2H2 Zn finger 411..431 CDD:275368 6/21 (29%)
ZXDANP_009087.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..89
Required for interaction with ZXDC. /evidence=ECO:0000269|PubMed:17493635 267..573 86/347 (25%)
C2H2 Zn finger 269..291 CDD:275368 5/21 (24%)
zf-C2H2_aberr 300..445 CDD:293622 41/167 (25%)
zf-C2H2 300..324 CDD:278523 4/27 (15%)
C2H2 Zn finger 302..324 CDD:275368 4/21 (19%)
C2H2 Zn finger 332..354 CDD:275368 8/21 (38%)
zf-H2C2_2 346..369 CDD:290200 8/23 (35%)
C2H2 Zn finger 362..382 CDD:275368 5/19 (26%)
C2H2 Zn finger 391..413 CDD:275368 5/21 (24%)
C2H2 Zn finger 425..444 CDD:275368 6/18 (33%)
COG5048 <437..568 CDD:227381 41/149 (28%)
C2H2 Zn finger 452..474 CDD:275368 6/21 (29%)
zf-H2C2_2 467..493 CDD:290200 9/25 (36%)
C2H2 Zn finger 482..504 CDD:275368 6/21 (29%)
C2H2 Zn finger 512..534 CDD:275370 6/21 (29%)
Required for transcriptional activation 572..699 13/68 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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