DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Opbp and ZNF142

DIOPT Version :9

Sequence 1:	NP_724479.1	Gene:	Opbp / 246618	FlyBaseID:	FBgn0050443	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001353219.1	Gene:	ZNF142 / 7701	HGNCID:	12927	Length:	1887	Species:	Homo sapiens

Alignment Length:	623	Identity:	137/623 - (21%)
Similarity:	215/623 - (34%)	Gaps:	212/623 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GDLSGGALQQEFLY---CESCGNVYEDTE---SYDRAHGPQAGCCTGASGELDFIEEVAEDCI-- 75
            |...|..|.::..|   |..|..:..:.:   .:.|:||      .|..|||..::.:....:
Human   235 GSQQGMELHRQAHYPFHCSHCSFIGSNVKLFRQHQRSHG------AGTQGELSAVQGLPSQELLP 293

  Fly    76 -----------SEEVGEEDIVYADVPLWELVEEVPANVKAEKDQNEPSNSDR------------- 116
                       |:|.|      ..:|..|..||  .||:.|:..:...:|.:
Human   294 APKLPPGEREPSQEAG------TPLPGQETAEE--ENVEKEEKSDTQKDSQKAVDKGQGAQRLEG 350

  Fly   117 ------------YFCYDCHSIFENRNKAEEHI----------CPRAESGGSSQQDGDAKAPVRRK 159
                        :.|.:|...|:.|....||:          ||..:...:|:  ...|..:.|:
Human   351 DVVSGTESLFKTHMCPECKRCFKKRTHLVEHLHLHFPDPSLQCPNCQKFFTSK--SKLKTHLLRE 413

  Fly   160 LASVSARTGP--------RDA----------------SSVISCGICNTVFSSEKFLKFHMRIHEN 200
            |.. .|...|        |:|                |...:|.:|...|...:.||.|::.|..
Human   414 LGE-KAHHCPLCHYSAVERNALNRHMASMHEDISNFYSDTYACPVCREEFRLSQALKEHLKSHTA 477

  Fly   201 RAPKSIQDALPIGAHQQ---YSELDQ--------------------------------------- 223
            .|   ..:.||:...|:   |:..|:
Human   478 AA---AAEPLPLRCFQEGCSYAAPDRKAFIKHLKETHGVRAVECRHHSCPMLFATAEAMEAHHKS 539

  Fly   224 ---FYCEICN-KSFDETLLTVHKQMHQQESSEIMCSICNRKFENEVTYQ-------MHQKIHEKP 277
               |:|..|: ...::.|...||:.....|.|:.|:.|.....|.|.||       .|:|||:.|
Human   540 HYAFHCPHCDFACSNKHLFRKHKKQGHPGSEELRCTFCPFATFNPVAYQDHVGKMHAHEKIHQCP 604

  Fly   278 RDSESSRKLAQRTSLDKEKPGFPCQYC---ERVFTRPFEKVKHERVHTGEKPYACEVCGKTFR-V 338
            .                      |.:.   :||.      ::|..:||||||:.||:|..|.| |
Human   605 E----------------------CNFATAHKRVL------IRHMLLHTGEKPHKCELCDFTCRDV 641

  Fly   339 SYSLTLHLRTHTNIRPYVCTVCNKRFKSHQVYSHHLRIHSSERQFSCDACPKTFRTSVQLYAHKN 403
            || |:.|:.||:|.:.|:||.|....|.......|:|.|:.:.::.|:.|......:.||.:||.
Human   642 SY-LSKHMLTHSNTKDYMCTECGYVTKWKHYLRVHMRKHAGDLRYQCNQCSYRCHRADQLSSHKL 705

  Fly   404 THT-KPYRCAVCNRPFSSMYAVKNHMQTHKEISSKGSVGSGTP-----------NIKSAATS--- 453
            .|. |...|.||      .:|.|...:..|.::|:...|:..|           ..|.|..|
Human   706 RHQGKSLMCEVC------AFACKRKYELQKHMASQHHPGTPAPLYPCHYCSYQSRHKQAVLSHEN 764

  Fly   454 -KSQAAGKFYCNTCGAEYARLFA---LRLHMKSAHGLV 487
             |.....:|:|..|  :| |.|:   |..|.:.|||.|
Human   765 CKHTRLREFHCALC--DY-RTFSNTTLLFHKRKAHGYV 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opbp	NP_724479.1	C2H2 Zn finger	254..274	CDD:275368	8/26 (31%)
		C2H2 Zn finger	301..321	CDD:275368	4/22 (18%)
		zf-H2C2_2	316..336	CDD:290200	10/19 (53%)
		C2H2 Zn finger	329..349	CDD:275368	10/20 (50%)
		zf-H2C2_2	341..366	CDD:290200	9/24 (38%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		C2H2 Zn finger	411..431	CDD:275368	5/19 (26%)
ZNF142	NP_001353219.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	4/21 (19%)
		C2H2 Zn finger	421..438	CDD:275368	3/16 (19%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		C2H2 Zn finger	545..566	CDD:275368	5/20 (25%)
		C2H2 Zn finger	574..595	CDD:275368	6/20 (30%)
		zf-H2C2_5	601..625	CDD:404746	7/51 (14%)
		C2H2 Zn finger	603..623	CDD:275368	5/47 (11%)
		C2H2 Zn finger	631..651	CDD:275368	10/20 (50%)
		C2H2 Zn finger	659..679	CDD:275368	6/19 (32%)
		C2H2 Zn finger	687..707	CDD:275368	6/19 (32%)
		C2H2 Zn finger	714..731	CDD:275368	6/22 (27%)
		PHA03247	928..>1219	CDD:223021
		C2H2 Zn finger	1306..1353	CDD:275368
		C2H2 Zn finger	1373..1394	CDD:275368
		C2H2 Zn finger	1402..1422	CDD:275368
		C2H2 Zn finger	1430..1451	CDD:275368
		C2H2 Zn finger	1626..1646	CDD:275368
		C2H2 Zn finger	1654..1674	CDD:275368
		C2H2 Zn finger	1682..1702	CDD:275368
		C2H2 Zn finger	1710..1730	CDD:275368
		zf-H2C2_2	1723..1747	CDD:404364
		C2H2 Zn finger	1738..1759	CDD:275368
		C2H2 Zn finger	1767..1787	CDD:275368
		C2H2 Zn finger	1795..1815	CDD:275368
		C2H2 Zn finger	1823..1843	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010