DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Opbp and ZNF76

DIOPT Version :9

Sequence 1:	NP_724479.1	Gene:	Opbp / 246618	FlyBaseID:	FBgn0050443	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_011513148.1	Gene:	ZNF76 / 7629	HGNCID:	13149	Length:	591	Species:	Homo sapiens

Alignment Length:	298	Identity:	93/298 - (31%)
Similarity:	136/298 - (45%)	Gaps:	62/298 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 QKIHEK--PRDSESSRKLAQRTSLDKEKPGFPCQY--CERVFTRPFEKVKHERVHTGEKPYACEV 331
            |.:|:.  ||:.: .:::..|        .|.|.|  |.|::|.......|||.|||::||.|:.
Human   156 QVLHDSQIPRNGK-GQQVGDR--------AFRCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDF 211

  Fly   332 --CGKTFRVSYSLTLHLRTHTNIRPYVC--TVCNKRFKSHQVYSHHLRIHSSERQFSC--DACPK 390
              |||.|...|.|..|:||||..:||.|  .:|:|.||:......|:|.|:.||.|.|  :.|.:
Human   212 PSCGKAFATGYGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGERPFQCPFEGCGR 276

  Fly   391 TFRTSVQLYAHKNTHT--KPYRCAV--CNRPFSSMYAVKNHMQTHKEISSKGSV----GSGTPNI 447
            :|.||.....|..|||  :||.|..  |.|.|:|....|||::.|  ...|..|    |.|....
Human   277 SFTTSNIRKVHVRTHTGERPYTCPEPHCGRGFTSATNYKNHVRIH--TGEKPYVCTVPGCGKRFT 339

  Fly   448 KSAATSKSQA----AGKFYCNTCGAEYARLFALRLHMKSAHGLVEEQENPATSTDAAHVAETDDS 508
            :.::..|...    ...:.|:|||..|.:...|.:|.:||||.:|               .|::|
Human   340 EYSSLYKHHVVHTHCKPYTCSTCGKTYRQTSTLAMHKRSAHGELE---------------ATEES 389

  Fly   509 ETAV-----LIAAAEAD---------AAYINAVVNDVD 532
            |.|:     |.||:.|:         .||::.|..:.|
Human   390 EQALYEQQQLEAASAAEESPPPKRPRIAYLSEVKEERD 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opbp	NP_724479.1	C2H2 Zn finger	254..274	CDD:275368	1/2 (50%)
		C2H2 Zn finger	301..321	CDD:275368	8/21 (38%)
		zf-H2C2_2	316..336	CDD:290200	12/21 (57%)
		C2H2 Zn finger	329..349	CDD:275368	9/21 (43%)
		zf-H2C2_2	341..366	CDD:290200	12/26 (46%)
		C2H2 Zn finger	357..377	CDD:275368	7/21 (33%)
		C2H2 Zn finger	385..405	CDD:275368	6/21 (29%)
		C2H2 Zn finger	411..431	CDD:275368	8/21 (38%)
ZNF76	XP_011513148.1	C2H2 Zn finger	179..201	CDD:275368	8/21 (38%)
		zf-H2C2_2	193..220	CDD:290200	13/26 (50%)
		COG5048	204..>262	CDD:227381	23/57 (40%)
		C2H2 Zn finger	209..231	CDD:275368	9/21 (43%)
		zf-H2C2_2	224..250	CDD:290200	12/25 (48%)
		zf-C2H2_aberr	237..358	CDD:293622	37/122 (30%)
		C2H2 Zn finger	239..261	CDD:275368	7/21 (33%)
		zf-H2C2_2	253..280	CDD:290200	9/26 (35%)
		C2H2 Zn finger	269..291	CDD:275368	6/21 (29%)
		zf-H2C2_2	285..310	CDD:290200	10/24 (42%)
		C2H2 Zn finger	299..321	CDD:275368	8/21 (38%)
		zf-H2C2_2	313..339	CDD:290200	8/27 (30%)
		C2H2 Zn finger	329..351	CDD:275368	3/21 (14%)
		C2H2 Zn finger	359..377	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000