DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opbp and znf143

DIOPT Version :9

Sequence 1:	NP_724479.1	Gene:	Opbp / 246618	FlyBaseID:	FBgn0050443	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_012816676.1	Gene:	znf143 / 595042	XenbaseID:	XB-GENE-1012504	Length:	632	Species:	Xenopus tropicalis

Alignment Length:	610	Identity:	140/610 - (22%)
Similarity:	215/610 - (35%)	Gaps:	148/610 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GGALQQEFLYCESCGNVYEDTESYDRAHGPQAGCCTGASGELDFIEEVAED-------CISEEVG 80
            ||...|....|.:  ....|.||.|...|......|.|.|...:|:...:|       .|..|.|
Frog    19 GGGEAQHVTLCLT--EAVADGESMDTMEGMSLQAVTLADGSTAYIQHNTKDGKLMEGQVIQLEDG 81

  Fly    81 E----------EDIVYADVPLWELVEEVPANV-KAEKDQNEPSN------SDRYFCYDCHSIFEN 128
            .          :|:...|....:|.:...|.: .:.||..:.|:      .|....|..|::  .
Frog    82 SAAYVQHVPKGDDLSLEDGQAVQLEDGTTAYIHHSSKDSYDQSSVQAVQLEDGTTAYIHHAV--Q 144

  Fly   129 RNKAEEHICPRAES------GGSSQQDGDAKAPVRRKLASVSARTGPRDASSVISCGICNTVFSS 187
            ..:::..:..:|:.      .|.:..|.|..:.:.:..|.||...|....|:.:
Frog   145 VPQSDTILAIQADGTVAGLHTGEASIDPDTISALEQYAAKVSIEGGEGAGSNAL----------- 198

  Fly   188 EKFLKFHMRIHENRAPKSIQDALPIGAH-----QQYSELDQFYC--EICNKSFDET-LLTVHKQM 244
                     |:|:.:.|.:|..|..|:.     .|.:| ..|.|  |.|.|.:... .|.||::.
Frog   199 ---------INESESEKKMQIVLSHGSRIPAKPPQTNE-KAFRCDYEGCGKLYTTAHHLKVHERS 253

  Fly   245 HQQESSEIMCSI--CNRKFENEVTYQMHQKIHEKPRDSESSRKLAQRTSLDKEKP--GFPCQYCE 305
            |..: ....|..  |.:.|..........|...............:.||:..|.|  |.|....:
Frog   254 HTGD-RPYQCDHGGCRKAFATAPASPRKDKAKASGPSEGEDHLPPEETSVPPEVPEEGRPQNPGQ 317

  Fly   306 RVFTRPFEKV----------------KHERVHTGEKPYAC--EVCGKTFRVSYSLTLHLRTHTNI 352
            |...|....|                .|.|.|||||||.|  |.|.|:|:.|..|..|:||||..
Frog   318 RGRVRRHRIVSGVQGIQKTADGYGLKSHVRTHTGEKPYRCSEENCTKSFKTSGDLQKHVRTHTGE 382

  Fly   353 RPYVCTV--CNKRFKSHQVYSHHLRIHSSERQFSCD--ACPKTFRTSVQLYAHKNTHT--KPYRC 411
            ||:.|..  |.:.|.:..:...|:|.|:.||.:.|.  .|.:.|.::.....|...||  |||.|
Frog   383 RPFKCPFEGCGRSFTTSNIRKVHIRTHTGERPYYCSEPGCGRAFASATNYKNHVRIHTGEKPYVC 447

  Fly   412 AV--CNRPF---SSMYAVKNH-MQTHKEISSKGSVGSGTPNIKSAATSKSQAAGKFYCNTCGAEY 470
            .|  |::.|   ||:|  |:| :.||.:                          .:.||.||..|
Frog   448 TVPGCDKRFTEYSSLY--KHHVVHTHSK--------------------------PYNCNHCGKTY 484

  Fly   471 ARLFALRLHMKSAHG----LVEEQEN------P-----------ATSTDAAHVAETDDSETAVLI 514
            .::..|.:|.::||.    :.||||:      |           .|..|.....:|..|...:.:
Frog   485 KQISTLAMHKRTAHNDTEPIEEEQESFFVPQPPDEVIKGSQITYVTGVDGEDGIQTTQSGQQLAL 549

  Fly   515 AAAEADAAYINAVVNDVDIVGTVPT 539
            .|.:. .:::..|..|:....|..|
Frog   550 IAQDG-TSHVAIVAQDLSAFHTSAT 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opbp	NP_724479.1	C2H2 Zn finger	254..274	CDD:275368	4/21 (19%)
		C2H2 Zn finger	301..321	CDD:275368	5/35 (14%)
		zf-H2C2_2	316..336	CDD:290200	13/21 (62%)
		C2H2 Zn finger	329..349	CDD:275368	9/21 (43%)
		zf-H2C2_2	341..366	CDD:290200	11/26 (42%)
		C2H2 Zn finger	357..377	CDD:275368	5/21 (24%)
		C2H2 Zn finger	385..405	CDD:275368	4/21 (19%)
		C2H2 Zn finger	411..431	CDD:275368	9/25 (36%)
znf143	XP_012816676.1	C2H2 Zn finger	232..254	CDD:275368	7/21 (33%)
		DUF1644	253..384	CDD:369526	35/131 (27%)
		COG5048	<331..482	CDD:227381	54/178 (30%)
		C2H2 Zn finger	357..379	CDD:275368	9/21 (43%)
		C2H2 Zn finger	387..409	CDD:275368	5/21 (24%)
		C2H2 Zn finger	417..439	CDD:275368	4/21 (19%)
		C2H2 Zn finger	447..469	CDD:275368	9/23 (39%)
		C2H2 Zn finger	477..496	CDD:275368	7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910