DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opbp and ZNF583

DIOPT Version :9

Sequence 1:	NP_724479.1	Gene:	Opbp / 246618	FlyBaseID:	FBgn0050443	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_005258615.1	Gene:	ZNF583 / 147949	HGNCID:	26427	Length:	570	Species:	Homo sapiens

Alignment Length:	484	Identity:	131/484 - (27%)
Similarity:	196/484 - (40%)	Gaps:	84/484 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 SGELDFIEEVAEDCISEEVGEEDIVYADVPLWELV---EEVPANVKAEKDQN---EPSNSDRYFC 119
            |..||: ..:.|||.||:..:..:...:|.|.:|:   :|:...|: .|:.|   :..:.|..|
Human   111 SYSLDY-PSLREDCQSEDWYKNQLGSQEVHLSQLIITHKEILPEVQ-NKEYNKSWQTFHQDTIF- 172

  Fly   120 YDCHSIFENRNKAEEHICPRAESGGSSQQDGDAKAPVRRKLASVSARTGPRDASSVISCGICNTV 184
             |....|..:.||.:|...:......|.:....|..|.:||               :.|..|..|
Human   173 -DIQQSFPTKEKAHKHEPQKKSYRKKSVEMKHRKVYVEKKL---------------LKCNDCEKV 221

  Fly   185 FSSEKFLKFHMRIHENRAPKSIQDALPIGAHQQYSELDQFYCEICNKSFDETL-LTVHKQMHQQE 248
            |:....|..|.|||....|                    :.|..|.|:|.::. |..||::|..|
Human   222 FNQSSSLTLHQRIHTGEKP--------------------YACVECGKTFSQSANLAQHKRIHTGE 266

  Fly   249 SSEIMCSICNRKFENEVTYQMHQKIH--EKPRDSESSRK----LAQRTSLDK----EKPGFPCQY 303
             ....|..|.:.|........||::|  |||...:..:|    :|..|...:    |:| |.|..
Human   267 -KPYECKECRKAFSQNAHLAQHQRVHTGEKPYQCKECKKAFSQIAHLTQHQRVHTGERP-FECIE 329

  Fly   304 CERVFTRPFEKVKHERVHTGEKPYACEVCGKTFRVSYSLTLHLRTHTNIRPYVCTVCNKRFKSHQ 368
            |.:.|:......:|:|:|||||||.|.||||.|.....|.:|.|.||..|||.|..|.|.|..:.
Human   330 CGKAFSNGSFLAQHQRIHTGEKPYVCNVCGKAFSHRGYLIVHQRIHTGERPYECKECRKAFSQYA 394

  Fly   369 VYSHHLRIHSSERQFSCDACPKTFRTSVQLYAHKNTHT--KPYRCAVCNRPFSSMYAVKNHMQTH 431
            ..:.|.|:|:.|:.:.|..|.|.|.....|..|:..||  |||.|..|.:.||:..::..|.::|
Human   395 HLAQHQRVHTGEKPYECKVCRKAFSQIAYLDQHQRVHTGEKPYECIECGKAFSNSSSLAQHQRSH 459

  Fly   432 --------KEISSKGSVGSGTPNIKSAATSKSQAAGKFYCNTCGAEYARLFALRLHMKSAHGLVE 488
                    ||.....|..:|....:...|.:.    .:.||.||..::...:|.||.:     :.
Human   460 TGEKPYMCKECRKTFSQNAGLAQHQRIHTGEK----PYECNVCGKAFSYSGSLTLHQR-----IH 515

  Fly   489 EQENPATSTDA-------AHVAETDDSET 510
            ..|.|....|.       ||:|..:...|
Human   516 TGERPYECKDCRKSFRQRAHLAHHERIHT 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opbp	NP_724479.1	C2H2 Zn finger	254..274	CDD:275368	5/19 (26%)
		C2H2 Zn finger	301..321	CDD:275368	5/19 (26%)
		zf-H2C2_2	316..336	CDD:290200	14/19 (74%)
		C2H2 Zn finger	329..349	CDD:275368	9/19 (47%)
		zf-H2C2_2	341..366	CDD:290200	12/24 (50%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		C2H2 Zn finger	411..431	CDD:275368	5/19 (26%)
ZNF583	XP_005258615.1	C2H2 Zn finger	355..375	CDD:275368	9/19 (47%)
		zf-H2C2_2	367..392	CDD:290200	12/24 (50%)
		C2H2 Zn finger	383..403	CDD:275368	6/19 (32%)
		zf-H2C2_2	395..420	CDD:290200	8/24 (33%)
		C2H2 Zn finger	411..431	CDD:275368	6/19 (32%)
		zf-H2C2_2	423..448	CDD:290200	10/24 (42%)
		C2H2 Zn finger	439..459	CDD:275368	5/19 (26%)
		zf-H2C2_2	451..476	CDD:290200	4/24 (17%)
		C2H2 Zn finger	467..487	CDD:275368	4/19 (21%)
		zf-H2C2_2	480..504	CDD:290200	5/27 (19%)
		C2H2 Zn finger	495..515	CDD:275368	7/24 (29%)
		zf-H2C2_2	507..532	CDD:290200	6/29 (21%)
		C2H2 Zn finger	523..543	CDD:275368	4/19 (21%)
		KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		COG5048	210..543	CDD:227381	105/378 (28%)
		C2H2 Zn finger	215..235	CDD:275368	7/19 (37%)
		zf-H2C2_2	227..252	CDD:290200	10/44 (23%)
		C2H2 Zn finger	243..263	CDD:275368	7/19 (37%)
		zf-H2C2_2	255..280	CDD:290200	8/25 (32%)
		C2H2 Zn finger	271..291	CDD:275368	5/19 (26%)
		zf-H2C2_2	283..308	CDD:290200	7/24 (29%)
		C2H2 Zn finger	299..319	CDD:275368	3/19 (16%)
		zf-H2C2_2	311..336	CDD:290200	7/25 (28%)
		C2H2 Zn finger	327..347	CDD:275368	5/19 (26%)
		zf-H2C2_2	340..364	CDD:290200	15/23 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000