DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opbp and ZNF418

DIOPT Version :9

Sequence 1:	NP_724479.1	Gene:	Opbp / 246618	FlyBaseID:	FBgn0050443	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001303956.1	Gene:	ZNF418 / 147686	HGNCID:	20647	Length:	697	Species:	Homo sapiens

Alignment Length:	517	Identity:	140/517 - (27%)
Similarity:	206/517 - (39%)	Gaps:	86/517 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SGGALQQEFLYCESCGNVYEDTES---YDRAHGPQAGCCTGASGELDFIEE----VAEDCISEEV 79
            |.|.|.||..:.....|...:.||   :...|.....|...:|.:..|:::    ..|:|...|.
Human   192 SSGLLLQEATHTGEKSNSKPECESPFQWGDTHYSCGECMKHSSTKHVFVQQQRLPSREECYCWEC 256

  Fly    80 GEEDIVYADVPLWELVEEVPANVKAEKDQNEPSNSDR-------YFCYDCHSIFENRNKAEEHIC 137
            |:....|..|                      ||..|       |.|.:|...|.::....:|
Human   257 GKSFSKYDSV----------------------SNHQRVHTGKRPYECGECGKSFSHKGSLVQH-- 297

  Fly   138 PRAESGGSSQQDGDAKAPVRRKLASVS---ARTGPRDASSVISCGICNTVFSSEKFLKFHMRIHE 199
            .|..:|....:.|:.......|.:.|.   ..||.|.    ..||.|...||....|..|.|:|.
Human   298 QRVHTGKRPYECGECGKSFSHKGSLVQHQRVHTGERP----YECGECGKSFSQNGTLIKHQRVHT 358

  Fly   200 NRAPKSIQDALPIG----------AHQQYSELDQFY-CEICNKSFDET-LLTVHKQMHQQESSEI 252
            ...|...::.   |          .||:....::.| ||.|.|.|.:. .||.|.::|.:| ...
Human   359 GERPYECEEC---GKCFTQKGNLIQHQRGHTSERPYECEECGKCFSQKGTLTEHHRVHTRE-RPY 419

  Fly   253 MCSICNRKFENEVTYQMHQKIH--EKPRD-----SESSRK---LAQRTSLDKEKPGFPCQYCERV 307
            .|..|.:.|..:...:.||:.|  |:|.:     ...|||   :..:.|...|:| :.|:.|.::
Human   420 ECGECGKSFSRKGHLRNHQRGHTGERPYECGECGKSFSRKGNLIQHQRSHTGERP-YECRECRKL 483

  Fly   308 FTRPFEKVKHERVHTGEKPYACEVCGKTFRVSYSLTLHLRTHTNIRPYVCTVCNKRFKSHQVYSH 372
            |......::|:||||||:||.|..|||:|:.|....:|.|.||..:|:.|:.|.|.|........
Human   484 FRGKSHLIEHQRVHTGERPYECNECGKSFQDSSGFRVHQRVHTGEKPFECSECGKSFPQSCSLLR 548

  Fly   373 HLRIHSSERQFSCDACPKTFRTSVQLYAHKNTHT--KPYRCAVCNRPFSSMYAVKNHMQTHKEIS 435
            |.|:|:.||.:.|..|.|:|..|..|..|:.|||  :||.|..|.:.|||:.   .|.:.|....
Human   549 HRRVHTGERPYECGECGKSFHQSSSLLRHQKTHTAERPYECRECGKFFSSLL---EHRRVHTGER 610

  Fly   436 SKGSVGSGTPNIKSAATSKSQ---AAGKFY-CNTCGAEYARLFALRLHMKSAHGLVEEQENP 493
            .......|....:.:|..|.|   ..||.| |:.||..:|..|:|..|.:     |...|.|
Human   611 PYECRECGKTFTRRSAHFKHQRLHTRGKPYECSECGKSFAETFSLTEHRR-----VHTGERP 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opbp	NP_724479.1	C2H2 Zn finger	254..274	CDD:275368	5/19 (26%)
		C2H2 Zn finger	301..321	CDD:275368	5/19 (26%)
		zf-H2C2_2	316..336	CDD:290200	13/19 (68%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		zf-H2C2_2	341..366	CDD:290200	9/24 (38%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		C2H2 Zn finger	411..431	CDD:275368	6/19 (32%)
ZNF418	NP_001303956.1	KRAB	26..>67	CDD:214630
		KRAB	26..65	CDD:279668
		C2H2 Zn finger	105..125	CDD:275368
		C2H2 Zn finger	253..273	CDD:275368	7/41 (17%)
		C2H2 Zn finger	281..301	CDD:275368	5/21 (24%)
		zf-H2C2_2	293..318	CDD:290200	4/26 (15%)
		COG5048	304..692	CDD:227381	112/381 (29%)
		C2H2 Zn finger	309..329	CDD:275368	3/19 (16%)
		zf-H2C2_2	321..346	CDD:290200	8/28 (29%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		zf-H2C2_2	350..374	CDD:290200	6/26 (23%)
		C2H2 Zn finger	365..385	CDD:275368	3/22 (14%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		C2H2 Zn finger	421..441	CDD:275368	5/19 (26%)
		zf-H2C2_2	433..458	CDD:290200	5/24 (21%)
		C2H2 Zn finger	449..469	CDD:275368	3/19 (16%)
		C2H2 Zn finger	477..497	CDD:275368	5/19 (26%)
		zf-H2C2_2	489..512	CDD:290200	13/22 (59%)
		C2H2 Zn finger	505..525	CDD:275368	8/19 (42%)
		zf-H2C2_2	518..540	CDD:290200	8/21 (38%)
		C2H2 Zn finger	533..553	CDD:275368	6/19 (32%)
		zf-H2C2_2	545..570	CDD:290200	9/24 (38%)
		C2H2 Zn finger	561..581	CDD:275368	7/19 (37%)
		zf-H2C2_2	573..598	CDD:290200	10/24 (42%)
		C2H2 Zn finger	589..606	CDD:275368	6/19 (32%)
		zf-H2C2_2	598..623	CDD:290200	4/27 (15%)
		C2H2 Zn finger	614..634	CDD:275368	4/19 (21%)
		C2H2 Zn finger	642..662	CDD:275368	7/24 (29%)
		zf-H2C2_2	654..679	CDD:290200	5/19 (26%)
		C2H2 Zn finger	670..690	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000