DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opbp and ZNF280A

DIOPT Version :9

Sequence 1:	NP_724479.1	Gene:	Opbp / 246618	FlyBaseID:	FBgn0050443	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_542778.2	Gene:	ZNF280A / 129025	HGNCID:	18597	Length:	542	Species:	Homo sapiens

Alignment Length:	382	Identity:	89/382 - (23%)
Similarity:	146/382 - (38%)	Gaps:	93/382 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 GGSSQQDGDAKAPVRRKLASVSARTG------------------PRDASSVISC-----GICNTV 184
            ||.::...|:|   |...:.:::|..                  |.|.||.||.     ||||:.
Human   156 GGRNESSPDSK---RLSTSDINSRDSKRVKLRDGIPGVPSLAVVPSDMSSTISTNTPSQGICNSS 217

  Fly   185 FSSEKFLKFHMRIHENRAPKSIQDALPIGAHQQYSELDQFYCEIC-----NKSFDE------TLL 238
            ...:..:.|.......:|..::.|.      ::.||......:|.     ||:||.      .||
Human   218 NHVQNGVTFPWPDANGKAHFNLTDP------ERASESALAMTDISSLASQNKTFDPKKENPIVLL 276

  Fly   239 T-----VHK---QMHQQESSEIMCSICNRKFENEVTYQMHQKIH---EKPRDSESSRKLAQRTSL 292
            :     .||   |..|:..:...|..|.:..:| :.:..|.|.|   ||.|:
Human   277 SDFYYGQHKGDGQPEQKTHTTFKCLSCVKVLKN-IKFMNHMKHHLEFEKQRN------------- 327

  Fly   293 DKEKPGFPCQYCERVFTRPFEKVKH-ERVHTGEKPYA-CEVCGKTFRVSYSLTLHLRTH--TNIR 353
            |..:....||:|.|.|..||:...| :.||....|.| |::|..:|.....|..|::.|  ....
Human   328 DSWEDHTTCQHCHRQFPTPFQLQCHIDSVHIAMGPSAVCKICELSFETDQVLLQHMKDHHKPGEM 392

  Fly   354 PYVCTVCNKRFKSH-QVYSHHLRIHSSERQFSCDACPKTFRTSVQLYAH--KNTHTKPYRCAVCN 415
            ||||.||:.|.... .|.:|....|.:.:...|..|.|.|:|::....|  :::..:..:|:.|.
Human   393 PYVCQVCHYRSSVFADVETHFRTCHENTKNLLCLFCLKLFKTAIPYMNHCWRHSRRRVLQCSKCR 457

  Fly   416 RPFSSM-----YAVKNHMQTHK------------EISSKGSVGSGTPNIKSAATSKS 455
            ..|.::     :..|:| ||.|            ::..:.||..|:..:.|...|.:
Human   458 LQFLTLKEEIEHKTKDH-QTFKKPEQLQGLPSETKVIIQTSVQPGSSGMASVIVSNT 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opbp	NP_724479.1	C2H2 Zn finger	254..274	CDD:275368	5/19 (26%)
		C2H2 Zn finger	301..321	CDD:275368	8/20 (40%)
		zf-H2C2_2	316..336	CDD:290200	7/21 (33%)
		C2H2 Zn finger	329..349	CDD:275368	5/19 (26%)
		zf-H2C2_2	341..366	CDD:290200	10/26 (38%)
		C2H2 Zn finger	357..377	CDD:275368	6/20 (30%)
		C2H2 Zn finger	385..405	CDD:275368	6/21 (29%)
		C2H2 Zn finger	411..431	CDD:275368	6/24 (25%)
ZNF280A	NP_542778.2	DUF4195	47..217	CDD:316361	16/63 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	105..185		6/31 (19%)
		C2H2 Zn finger	336..357	CDD:275368	8/20 (40%)
		C2H2 Zn finger	366..386	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..542		2/12 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910