DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Opbp and ZNF813

DIOPT Version :9

Sequence 1:	NP_724479.1	Gene:	Opbp / 246618	FlyBaseID:	FBgn0050443	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001004301.2	Gene:	ZNF813 / 126017	HGNCID:	33257	Length:	617	Species:	Homo sapiens

Alignment Length:	414	Identity:	120/414 - (28%)
Similarity:	171/414 - (41%)	Gaps:	65/414 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 KAEKDQNEPSNSDRYFCYDCHSIFEN-----RN------KAEEHICPRAESGGSSQQDGDA--KA 154
            |:..|.:..|.|.|..|.....|..|     ||      |.|.|:   .|......:.|.|  .:
Human   166 KSINDASSISTSQRISCRPKTHISNNYGNNFRNSSLLTQKQEVHM---REKSFQCNESGKAFNYS 227

  Fly   155 PVRRKLASVSARTGPRDASSVISCGICNTVFSSEKFLKFHMRIHENRAPKSIQDALPIGAHQQYS 219
            .:.||...:  ..|.:.    ..|.:|..||:.::.|..|.|.|....|
Human   228 SLLRKHQII--HLGEKQ----YKCDVCGKVFNRKRNLVCHRRCHTGEKP---------------- 270

  Fly   220 ELDQFYCEICNKSFDETL-LTVHKQMHQQESSEIMCSICNRKFENEVTYQMHQKIH--EKP-RDS 280
                :.|..|.|:|.:|. ||.|:::|..| ....|..|::.|..:...:.|::||  ||| :.:
Human   271 ----YRCNECGKTFSQTYSLTCHRRLHTGE-KPYKCEECDKAFSFKSNLKRHRRIHAGEKPYKCN 330

  Fly   281 ESSRKLAQRTSL-------DKEKPGFPCQYCERVFTRPFEKVKHERVHTGEKPYACEVCGKTFRV 338
            |..:..:|.:||       ..||| |.|..|.:.|:|......|.|:|||||||.|..|||||..
Human   331 ECGKTFSQTSSLTCHRRLHTGEKP-FKCNECGKTFSRKSSLTCHHRLHTGEKPYKCNECGKTFSQ 394

  Fly   339 SYSLTLHLRTHTNIRPYVCTVCNKRFKSHQVYSHHLRIHSSERQFSCDACPKTFRTSVQLYAHKN 403
            ..:|..|.|.||..:||.|..|.|.|......:.|.|:||.|:.:.|..|.|||..:..|..||.
Human   395 ELTLKCHRRLHTGEKPYKCNECGKVFNKKANLARHHRLHSGEKPYKCTECVKTFSRNSALVIHKA 459

  Fly   404 TH--TKPYRCAVCNRPFSSMYAVKNHMQTH--KEISSKGSVGSGTPNIKSAATSKSQAAGK--FY 462
            .|  .|.|:|..|.:.||.:.|:..|...|  ::.......|.|.......|.......|:  :.
Human   460 IHIGEKRYKCNECGKTFSRISALVIHTAIHTGEKPYKCNECGKGFNRKTHLACHHRLHTGEKPYK 524

  Fly   463 CNTCGAEYARLFALRLHMKSAHGL 486
            ||.||    ::|..:.|:...|.|
Human   525 CNECG----KVFNRKTHLAHHHRL 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opbp	NP_724479.1	C2H2 Zn finger	254..274	CDD:275368	4/19 (21%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		zf-H2C2_2	316..336	CDD:290200	13/19 (68%)
		C2H2 Zn finger	329..349	CDD:275368	9/19 (47%)
		zf-H2C2_2	341..366	CDD:290200	11/24 (46%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		C2H2 Zn finger	411..431	CDD:275368	6/19 (32%)
ZNF813	NP_001004301.2	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	191..602	CDD:227381	113/389 (29%)
		C2H2 Zn finger	217..237	CDD:275368	4/21 (19%)
		zf-H2C2_2	230..254	CDD:290200	7/29 (24%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		zf-H2C2_2	257..282	CDD:290200	9/44 (20%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	285..309	CDD:290200	7/24 (29%)
		C2H2 Zn finger	301..321	CDD:275368	4/19 (21%)
		zf-H2C2_2	313..338	CDD:290200	7/24 (29%)
		C2H2 Zn finger	329..349	CDD:275368	4/19 (21%)
		zf-H2C2_2	341..366	CDD:290200	9/25 (36%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		zf-H2C2_2	369..394	CDD:290200	15/24 (63%)
		C2H2 Zn finger	385..405	CDD:275368	9/19 (47%)
		zf-H2C2_2	398..421	CDD:290200	10/22 (45%)
		C2H2 Zn finger	413..433	CDD:275368	6/19 (32%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		C2H2 Zn finger	497..517	CDD:275368	3/19 (16%)
		zf-H2C2_2	509..534	CDD:290200	7/28 (25%)
		C2H2 Zn finger	525..545	CDD:275368	8/24 (33%)
		C2H2 Zn finger	553..573	CDD:275368
		zf-H2C2_2	565..590	CDD:290200
		C2H2 Zn finger	581..601	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000