DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Opbp and zgc:194336

DIOPT Version :9

Sequence 1:	NP_724479.1	Gene:	Opbp / 246618	FlyBaseID:	FBgn0050443	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001124130.1	Gene:	zgc:194336 / 100170823	ZFINID:	ZDB-GENE-080723-34	Length:	496	Species:	Danio rerio

Alignment Length:	462	Identity:	128/462 - (27%)
Similarity:	177/462 - (38%)	Gaps:	60/462 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 FIEEVAEDCISEE---VGEEDIVYADVPLWE-------LVEEVPANVKAEKDQNEPSNSDRYFCY 120
            ||:|.:||...|:   |..||......||.|       ...|......|||...:...|....|.
Zfish     3 FIKEESEDLKIEDTFTVKHEDAEQITDPLKEESQDLGDFTNEERCTPTAEKTPEKADPSSSVSCR 67

  Fly   121 DCHSIFENRNKAEEHICPRAESGG---SSQQDGDAKAPVRRKLASVSARTGPRDASSVISCGICN 182
            .|...|..:...:.|:  :..||.   |....|.:.:........:...||    .:..:||.|.
Zfish    68 QCGRRFGGQQSLQAHL--KTHSGEKPFSCDHCGKSFSKKINLKVHIRIHTG----ETPYTCGQCG 126

  Fly   183 TVFSSEKFLKFHMRIHENRAPKSIQ--DALPIGAHQQ-----YSELDQFYCEICNKSFD-ETLLT 239
            ..|.....|..|.|||..|..|..|  .:.|.|...:     :|....|.|. |.|||. ...|.
Zfish   127 KSFRCRDALTCHRRIHSERCVKCAQCGKSFPDGTCMRNHLLVHSGEKPFRCR-CGKSFRFSRNLK 190

  Fly   240 VHKQMHQQESSEIMCSICNRKFENEVTYQMHQKIHEKPR---DSESSRKLAQRTSLDK------- 294
            .|.::|..| ...:|.:|.:.|.::...:.|.:||...|   .:|..:..|.:.:|..
Zfish   191 THMRIHSGE-RPFVCGVCGKSFCHKAGLKNHSRIHSGERLFSCAECGKSFAYKATLSAHESAAHR 254

  Fly   295 -EKPGFPCQYCERVFTRPFEKVKHERVHTGEKPYACEVCGKTFRVSYSLTLHLRTHTNIRPYVCT 358
             |.| ..|::|.:.|::......|.|:|:||.||.|..|||:||...:|..|..|||...|:.|.
Zfish   255 GESP-HACRHCGKSFSQKGNLKTHMRIHSGEMPYECVQCGKSFRRKETLNTHAHTHTGDSPHTCK 318

  Fly   359 VCNKRFKSHQVYSHHLRIHSSERQFSCDACPKTFRTSVQLYAHKNTHTKPYR--CAVCNRPFSSM 421
            :|.|.|........|:||||.||.|.|..|.::|.....|..|..||:...|  |..|.:.|...
Zfish   319 LCGKSFSRKGNLKTHMRIHSGERPFICAHCGQSFGRKETLNYHMKTHSSEDRFICQHCGKSFPDK 383

  Fly   422 YAVKNHMQTHKEISSKGSVGSGTPNIKSAATSKSQAAGKFYCNTCGAEYARLFALRLHMKSAHGL 486
            ...|.|...|        .|...|:..|..||:.    .|.|..||..:.....||.||:
Zfish   384 EQQKRHKAAH--------AGDLPPSDLSGQTSEK----AFVCQQCGKSFTVKGNLRTHMR----- 431

  Fly   487 VEEQENP 493
            |...|.|
Zfish   432 VHTGEKP 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opbp	NP_724479.1	C2H2 Zn finger	254..274	CDD:275368	4/19 (21%)
		C2H2 Zn finger	301..321	CDD:275368	5/19 (26%)
		zf-H2C2_2	316..336	CDD:290200	11/19 (58%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		zf-H2C2_2	341..366	CDD:290200	10/24 (42%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..405	CDD:275368	5/19 (26%)
		C2H2 Zn finger	411..431	CDD:275368	5/19 (26%)
zgc:194336	NP_001124130.1	COG5048	65..487	CDD:227381	111/400 (28%)
		C2H2 Zn finger	66..86	CDD:275368	4/21 (19%)
		zf-H2C2_2	78..102	CDD:290200	5/25 (20%)
		C2H2 Zn finger	94..114	CDD:275368	1/19 (5%)
		zf-H2C2_2	106..131	CDD:290200	6/28 (21%)
		C2H2 Zn finger	122..142	CDD:275368	7/19 (37%)
		C2H2 Zn finger	149..169	CDD:275368	3/19 (16%)
		C2H2 Zn finger	177..196	CDD:275368	7/19 (37%)
		zf-H2C2_2	188..211	CDD:290200	6/23 (26%)
		C2H2 Zn finger	204..224	CDD:275368	4/19 (21%)
		C2H2 Zn finger	232..253	CDD:275368	3/20 (15%)
		C2H2 Zn finger	261..281	CDD:275368	5/19 (26%)
		zf-H2C2_2	273..298	CDD:290200	12/24 (50%)
		C2H2 Zn finger	289..309	CDD:275368	8/19 (42%)
		zf-C2H2	315..337	CDD:278523	6/21 (29%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		C2H2 Zn finger	345..365	CDD:275368	5/19 (26%)
		C2H2 Zn finger	373..393	CDD:275368	5/19 (26%)
		C2H2 Zn finger	413..433	CDD:275368	7/24 (29%)
		zf-H2C2_2	425..449	CDD:290200	7/19 (37%)
		C2H2 Zn finger	441..461	CDD:275368
		zf-H2C2_2	453..478	CDD:290200
		C2H2 Zn finger	469..489	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000