Protein Alignment Ugt50B3 and UGT2A3

DIOPT Version :10

• Sequence 1: NP_724417.3
• Gene: Ugt50B3 / 246614
• FlyBaseID: FBgn0050438
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 141/523 - (26%)
• Similarity: 248/523 - (47%)
• Gaps: 94/523 - (17%)

  Fly     9 LIIWSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNIEGLLEV-TPAG 72
            :::|.|              ..||.:....:.:.||.|||.:|.|:     .:...|::. .|:.
Human    26 VLVWPC--------------DMSHWLNVKVILEELIVRGHEVTVLT-----HSKPSLIDYRKPSA 71

  Fly    73 L-VEYIH--------NYTNWDLLGSRMAGEMPIKPWDG----------LRYAFE-SCDAML-RDS 116
            | .|.:|        |....||..:.:.|   :..|..          :|...: .|::.: ..:
Human    72 LKFEVVHMPQDRTEENEIFVDLALNVLPG---LSTWQSVIKLNDFFVEIRGTLKMMCESFIYNQT 133

  Fly   117 ETKELTKKSFDLAILDGAFPECFLGLMYD-FKIPFMYINTVGFYTGSISTAGN----------PV 170
            ..|:|.:.::|:.::|...| |. .||.: ..:||:       .|..||..||          |:
Human   134 LMKKLQETNYDVMLIDPVIP-CG-DLMAELLAVPFV-------LTLRISVGGNMERSCGKLPAPL 189

  Fly   171 SYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVS 235
            ||...|  .:..||.|...||..|:.:.:   |.|.::....:....|.....:..|..:...|
Human   190 SYVPVP--MTGLTDRMTFLERVKNSMLSV---LFHFWIQDYDYHFWEEFYSKALGRPTTLCETV- 248

  Fly   236 FILQNGHAVL---------SYPRAFNPNVAEVACIHCRPARKLPR------NLEEFIGASGASGF 285
                 |.|.:         .:|:.:.||...|..:||:||:.||:      .:|.|:.:||..|.
Human   249 -----GKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHCKPAKALPKINFYLQEMENFVQSSGEDGI 308

  Fly   286 IYVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGH 350
            :..|:||..:  |:.|...:::....|::|..|||:|:|...  ..:.:|.:|..|:||.|:|||
Human   309 VVFSLGSLFQ--NVTEEKANIIASALAQIPQKVLWRYKGKKP--STLGANTRLYDWIPQNDLLGH 369

  Fly   351 PKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIM 415
            ||.:||:||||:..::|.:|||||:|.:|:|.|...|.|..:..|.|::::.:|:::..|.:|:.
Human   370 PKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALR 434

  Fly   416 KVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVA 480
            .||.:..|:.:|....::..||....||.|::|.|:|:||.||.||::.:.::||:|:|.:||:.
Human   435 TVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIG 499

  Fly   481 VYL 483
            ..|
Human   500 FLL 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_724417.3	Glycosyltransferase_GTB-type	43..480	CDD:471961	136/484 (28%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	141/523 (27%)