Protein Alignment Ugt50B3 and UGT2A3

DIOPT Version :9

• Sequence 1: NP_001260710.1
• Gene: Ugt50B3 / 246614
• FlyBaseID: FBgn0050438
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 141/523 - (26%)
• Similarity: 248/523 - (47%)
• Gaps: 94/523 - (17%)

  Fly     9 LIIWSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNIEGLLEV-TPAG 72
            :::|.|              ..||.:....:.:.||.|||.:|.|:     .:...|::. .|:.
Human    26 VLVWPC--------------DMSHWLNVKVILEELIVRGHEVTVLT-----HSKPSLIDYRKPSA 71

  Fly    73 L-VEYIH--------NYTNWDLLGSRMAGEMPIKPWDG----------LRYAFE-SCDAML-RDS 116
            | .|.:|        |....||..:.:.|   :..|..          :|...: .|::.: ..:
Human    72 LKFEVVHMPQDRTEENEIFVDLALNVLPG---LSTWQSVIKLNDFFVEIRGTLKMMCESFIYNQT 133

  Fly   117 ETKELTKKSFDLAILDGAFPECFLGLMYD-FKIPFMYINTVGFYTGSISTAGN----------PV 170
            ..|:|.:.::|:.::|...| |. .||.: ..:||:       .|..||..||          |:
Human   134 LMKKLQETNYDVMLIDPVIP-CG-DLMAELLAVPFV-------LTLRISVGGNMERSCGKLPAPL 189

  Fly   171 SYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVS 235
            ||...|  .:..||.|...||..|:.:.:   |.|.::....:....|.....:..|..:...|
Human   190 SYVPVP--MTGLTDRMTFLERVKNSMLSV---LFHFWIQDYDYHFWEEFYSKALGRPTTLCETV- 248

  Fly   236 FILQNGHAVL---------SYPRAFNPNVAEVACIHCRPARKLPR------NLEEFIGASGASGF 285
                 |.|.:         .:|:.:.||...|..:||:||:.||:      .:|.|:.:||..|.
Human   249 -----GKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHCKPAKALPKINFYLQEMENFVQSSGEDGI 308

  Fly   286 IYVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGH 350
            :..|:||..:  |:.|...:::....|::|..|||:|:|...  ..:.:|.:|..|:||.|:|||
Human   309 VVFSLGSLFQ--NVTEEKANIIASALAQIPQKVLWRYKGKKP--STLGANTRLYDWIPQNDLLGH 369

  Fly   351 PKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIM 415
            ||.:||:||||:..::|.:|||||:|.:|:|.|...|.|..:..|.|::::.:|:::..|.:|:.
Human   370 PKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALR 434

  Fly   416 KVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVA 480
            .||.:..|:.:|....::..||....||.|::|.|:|:||.||.||::.:.::||:|:|.:||:.
Human   435 TVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIG 499

  Fly   481 VYL 483
            ..|
Human   500 FLL 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	118/453 (26%)
		egt	<172..479	CDD:223071	99/321 (31%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	141/523 (27%)
		egt	<267..498	CDD:223071	83/234 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm40389
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.810