DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and ugt5b4

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001074161.1	Gene:	ugt5b4 / 791210	ZFINID:	ZDB-GENE-070112-2332	Length:	531	Species:	Danio rerio

Alignment Length:	562	Identity:	156/562 - (27%)
Similarity:	270/562 - (48%)	Gaps:	71/562 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKKIALFLIIWSCGTLAADILMA--TQGGT-------KSHKIPFWELAKGLISRGHNITFL--- 53
            |.:|:  |.::|.. ||...::||  .:.|.       .||.:....|.:.|.::|||||.:
Zfish     1 MNRKV--FHMLWPV-TLCLLLVMAPVVESGNVLVFPVDGSHWVNMNILVEALHAKGHNITVIRMS 62

  Fly    54 -SGFPADFN--------------IEGLLEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKPWDG-- 101
             |.:..:|:              .|.:||...:.|:..:.:.:.|..|      ::.::.|..
Zfish    63 DSWYIKEFSPHYTSITLKSSGGFSEDILETFASRLITILRDGSTWGRL------KLEMEMWQSSL 121

  Fly   102 --LRYAFESCDAMLRDSETKELTKKS-FDLAILDGAFPECFLGLMYD--FKIPFMY-INTVGFYT 160
              :....|....|:.|.:..:..||: :||.:.|   |..:.|::..  .|:|.:| :....|..
Zfish   122 KIMETEREMIINMIEDQQLIDSLKKTKYDLFLTD---PAMYGGVILGNYLKLPIVYNVRWAIFGE 183

  Fly   161 GSISTAGNPVSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREH-LGTQI 224
            |....|.:|:||  .|.......|.|:..||..|..|.|.......:::..|:.|:.|. :|..:
Zfish   184 GHFVIAPSPLSY--VPVAMLELPDRMSFLERVKNVVMYIITETQIAFLIAPTYNVLCERFIGPGV 246

  Fly   225 PHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVS 289
             :.:.:.:.....|.....|..|||...||:..:|...|:|::.||::||:|:.:||..|.|.:|
Zfish   247 -NLFNLVQGADLWLHRADFVFEYPRPTMPNIVYMAGFQCKPSKPLPKDLEDFVQSSGDHGVIVMS 310

  Fly   290 MGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLR 354
            :|:.:  ..:|:.:...:.:.||.||..::|:|:|.....  :.:|..:..|:||.|:|||||.|
Zfish   311 LGTII--GQLPDDVAEAIAEAFAELPQKIIWRYKGKRPSA--LGNNTLIMDWMPQNDLLGHPKTR 371

  Fly   355 AFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIH 419
            |||.|||...:.|.:|||||::...:..|...|.:|..|.|.|..:|..|:......|.:.:|::
Zfish   372 AFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLKTVKEVLY 436

  Fly   420 NPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLI 484
            :|.||.:.:...:|..|.....||.||:|.|:|:||.||.||:|.|..|.|:.|:.:||:.|.:.
Zfish   437 DPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILVLIS 501

  Fly   485 LLYVLILALRRIDFPYEKVRSLYSLMAPF---ITIAKTKSKK 523
            .:.::||             |:|:::..|   |.:.|||.|:
Zfish   502 AVSLIIL-------------SIYAVIRYFCCKICMRKTKIKR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	115/439 (26%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	99/307 (32%)
ugt5b4	NP_001074161.1	egt	12..501	CDD:223071	142/505 (28%)
ugt5b4	NP_001074161.1	UDPGT	27..531	CDD:278624	148/533 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810