DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	525	Identity:	150/525 - (28%)
Similarity:	234/525 - (44%)	Gaps:	62/525 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALFLIIWSCGTLAADI----LMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPAD------- 59
            ||.:.:..||   .|:    .:....|..||......:.:.|:.:.|::|.|.|..:.
Zfish     5 ALLVCLLLCG---VDVGWSGRVLVMPGEYSHWHNMRPVIEALVDKNHSVTVLVGSSSPTVPHTQK 66

  Fly    60 -------FNIEGLLEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAMLRD-- 115
                   |.:....|...|.:.:.||.:|| | ..::..||..:  |..:....|..|...|.
Zfish    67 ERFEYHVFKVNMEKEEADAAMRDMIHLFTN-D-TAAKYEGEFVM--WKVMSKFVEFGDVYFRGLF 127

  Fly   116 --SETKELTKKSFDLAILDGAFPECFLGLM-YDFKIPFMYINTVGFYTGSISTAGN---PVSYAI 174
              ...|.|...::|:...|...|  |..|| ....||.:......|...:....|.   |.||..
Zfish   128 DVGLLKTLRDSNYDVLFSDPMMP--FSDLMAQKLNIPQVISMRATFAYAAERLCGQMPAPPSYVP 190

  Fly   175 TPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTH-----------LVMREHLGTQIPHPY 228
            ........||.|:..||..|..:.|..::....|...|.           ..|.|.:|
Zfish   191 AVALTDHLTDRMSFMERVENMLLYIVHSIAFPLVATFTFDGYYSEILGKPTTMCETMG------- 248

  Fly   229 EMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSMGSS 293
                .|...|...:....|||.|.||...|..:||:||:.|.:.||||:.:||..|.:..|:||.
Zfish   249 ----KVDICLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKPLSKELEEFVQSSGDHGVVVFSLGSM 309

  Fly   294 VKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVT 358
            :|  |:.....:.:.....::|..|:|:|.|.:.:  .:..|.|:..|:||.|:|||||.:||:|
Zfish   310 IK--NLTSERANTIAAALGQIPQKVVWRYSGKTPE--TLAPNTKIYDWIPQNDLLGHPKTKAFIT 370

  Fly   359 HGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRY 423
            |||...::|.:|||||:|.:|:|.|...|....:..|.|:.||:.|:.:..|..|:..|::||.|
Zfish   371 HGGTNGLYEAIYHGVPMVGLPLFGDQPDNLLHIKTKGAAVVLDIHTMGSKDLVDALKAVVNNPSY 435

  Fly   424 RNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLILLYV 488
            :.|.....::..||....||.|:||.|:|:|:.||.||:..:..::|:||:.|| ||.:|:.:..
Zfish   436 KESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLD-VAAFLLSITA 499

  Fly   489 LILAL 493
            ||..|
Zfish   500 LITFL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	120/438 (27%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	103/317 (32%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	145/506 (29%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	86/239 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.810