DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and UGT2B15

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001067.2	Gene:	UGT2B15 / 7366	HGNCID:	12546	Length:	530	Species:	Homo sapiens

Alignment Length:	568	Identity:	173/568 - (30%)
Similarity:	272/568 - (47%)	Gaps:	89/568 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKKIALFLII-----WSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSG-----F 56
            ||..::||:|     :|.|:....::..|:   .||.|....:.:.|:.|||.:|.|:.     .
Human     3 LKWTSVFLLIQLSCYFSSGSCGKVLVWPTE---YSHWINMKTILEELVQRGHEVTVLTSSASTLV 64

  Fly    57 PADFNIEGLLEVTPAGLVEYIHNY-------------------TNWDLLGSRMAGEMPIKPWDGL 102
            .|..:....|||.|..|.:   ||                   |.|...     .::....|:..
Human    65 NASKSSAIKLEVYPTSLTK---NYLEDSLLKILDRWIYGVSKNTFWSYF-----SQLQELCWEYY 121

  Fly   103 RYAFESC-DAMLRDSETKELTKKSFDLAILDGAFPECFLGLMYDFKIPFMYI--NTVGFYTGSIS 164
            .|:.:.| ||:|......:|.:..||:.:.|...| |...|...|.|||:|.  .:|| ||...:
Human   122 DYSNKLCKDAVLNKKLMMKLQESKFDVILADALNP-CGELLAELFNIPFLYSLRFSVG-YTFEKN 184

  Fly   165 TAG--NPVSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHM---------YVMRRTHLVMRE 218
            ..|  .|.||  .|...|..:|.|...||..|        ::||         |.:::......|
Human   185 GGGFLFPPSY--VPVVMSELSDQMIFMERIKN--------MIHMLYFDFWFQIYDLKKWDQFYSE 239

  Fly   219 HLGTQIPHP---YEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGAS 280
            .||    .|   :|........|...:....:||.|.|||..|..:||:||:.||:.:|||:.:|
Human   240 VLG----RPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS 300

  Fly   281 GASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQ 345
            |.:|.:..|:||.:  :||.|...:|:....|::|..|||:::|...:  .:.||.:|.:||||.
Human   301 GENGIVVFSLGSMI--SNMSEESANMIASALAQIPQKVLWRFDGKKPN--TLGSNTRLYKWLPQN 361

  Fly   346 DILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQL 410
            |:|||||.:||:||||...::|.:|||:|:|.:|:|.|...|.|..:..|.|:.:|::|:|:..|
Human   362 DLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDL 426

  Fly   411 YKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYL 475
            ..|:..||::|.|:.:.....::..||....||.|::|.|:|:||.||.||:..:.|:||.||:.
Human   427 LNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHS 491

  Fly   476 LDVVAVYLILLYVLILALRRIDFPYEKVRSLYSLMAPFITIAKTKSKK 523
            |||:|..|..:..:|..:.:           :.|.. |..:||...||
Human   492 LDVIAFLLACVATVIFIITK-----------FCLFC-FRKLAKKGKKK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	134/446 (30%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	111/318 (35%)
UGT2B15	NP_001067.2	egt	8..508	CDD:223071	165/530 (31%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	161/536 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm40389
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.810