DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and UGT2B4

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_066962.2	Gene:	UGT2B4 / 7363	HGNCID:	12553	Length:	528	Species:	Homo sapiens

Alignment Length:	533	Identity:	160/533 - (30%)
Similarity:	262/533 - (49%)	Gaps:	67/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALFLIIWSC----GTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPA---DFNIE 63
            ||.||..||    |:....::..|:   .||.:....:...|:.|||.:|.|:...:   |.|..
Human     8 ALLLIQLSCYFSSGSCGKVLVWPTE---FSHWMNIKTILDELVQRGHEVTVLASSASISFDPNSP 69

  Fly    64 GLL--EVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKPW-----------------------DGLR 103
            ..|  ||.|..|.:     |.::.:..::     :|.|                       |.||
Human    70 STLKFEVYPVSLTK-----TEFEDIIKQL-----VKRWAELPKDTFWSYFSQVQEIMWTFNDILR 124

  Fly   104 YAFESC-DAMLRDSETKELTKKSFDLAILDGAFPECFLGLMYD-FKIPFMYINTVGFYTGSI--S 164
               :.| |.:......|:|.:..||:.:.|..||  |..|:.: .||||:|  ::.|..|..  .
Human   125 ---KFCKDIVSNKKLMKKLQESRFDVVLADAVFP--FGELLAELLKIPFVY--SLRFSPGYAIEK 182

  Fly   165 TAGN---PVSYAITPNFYSRFTDTMNLYERAINTAMQI-GQTLMHMYVMRRTHLVMREHLGTQIP 225
            .:|.   |.||  .|...|..:|.|...||..|....: .:....::.|::......|.||....
Human   183 HSGGLLFPPSY--VPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVLGRPTT 245

  Fly   226 HPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSM 290
            ....|::...::::| :....:|....|||..|..:||:||:.||:.:|||:.:||.:|.:..|:
Human   246 LSETMAKADIWLIRN-YWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSL 309

  Fly   291 GSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRA 355
            ||.|  :|..|...:::....|::|..|||:::|:..|...:  |.:|.:|:||.|:|||||.||
Human   310 GSMV--SNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGL--NTRLYKWIPQNDLLGHPKTRA 370

  Fly   356 FVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHN 420
            |:||||...::|.:|||:|:|.:|:|.|...|.|..:..|.|:.||..|:|:..|..|:..||::
Human   371 FITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVIND 435

  Fly   421 PRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLIL 485
            |.|:.:|....::..||....||.|::|.|:|:||.||.||:..:.::||:||:.|||....|..
Human   436 PLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLAC 500

  Fly   486 LYVLILALRRIDF 498
            :..:|..:.:..|
Human   501 VATVIFIITKCLF 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	128/441 (29%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	106/307 (35%)
UGT2B4	NP_066962.2	egt	8..512	CDD:223071	159/530 (30%)
UGT2B4	NP_066962.2	UDPGT	24..524	CDD:278624	153/517 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm40389
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.810