DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_082370.2	Gene:	Ugt2a3 / 72094	MGIID:	1919344	Length:	534	Species:	Mus musculus

Alignment Length:	530	Identity:	148/530 - (27%)
Similarity:	250/530 - (47%)	Gaps:	88/530 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIIWSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFL----------SGFPADF-NI 62
            :::|.|              ..||.:....:.:.|.:|||.:|.|          ...|..| ||
Mouse    26 VLVWPC--------------DMSHWLNLKTILEELGARGHEVTVLKYPSIIIDQSKRIPLHFENI 76

  Fly    63 EGLLEVTPAG---------LVEYIHNYTNWDLLGS------RMAGEMPIKPWDGLRYAFES-CDA 111
            ..|.|:..|.         .|..|.|.:.|:...:      ::.|:            ||| |.:
Mouse    77 PLLYEIETAENRLNEIANLAVNVIPNLSLWEAAKTLQDFFLQVTGD------------FESICRS 129

  Fly   112 MLRDSE-TKELTKKSFDLAILDGAFPECFLGLMYDFKIPFMYI--NTVGFY----TGSISTAGNP 169
            :|.:.: ..:|....:|:.::|...| |...:....:|||:|.  .::|:|    .|.:     |
Mouse   130 VLYNQKFMDKLRDAQYDVVVIDPVVP-CGELVAEVLQIPFVYTLRFSMGYYMEKHCGQL-----P 188

  Fly   170 VSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNV 234
            :..:..|...|..||.|...||..|...    :|:..|.:::......:...::     .:.|..
Mouse   189 IPLSYVPVVMSELTDNMTFTERVKNMMF----SLLFEYWLQQYDFAFWDQFYSE-----TLGRPT 244

  Fly   235 SFILQNGHAVL---------SYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSM 290
            :|....|.|.:         .:||.:.||...|..:||:||:.||:.:|||:.:||..|.:..|:
Mouse   245 TFCKTVGKADIWLIRTYWDVEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFVQSSGEHGVVVFSL 309

  Fly   291 GSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRA 355
            ||.||  |:.|...:::....|::|..|||:|.|...  ..:.||.:|..|:||.|:|||||.:|
Mouse   310 GSMVK--NLTEEKANLIASVLAQIPQKVLWRYSGKKP--ATLGSNTRLFNWIPQNDLLGHPKTKA 370

  Fly   356 FVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHN 420
            |:||||...::|.:|||||:|.:|:..|...|.|..|..|.|:|:.:.|:::..|..|:..||:.
Mouse   371 FITHGGTNGIYEAIYHGVPMVGVPMLGDQPHNIAHMEAKGAALKVSISTMTSTDLLSAVRAVINE 435

  Fly   421 PRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLIL 485
            |.|:.:|....::..||....||.|::|.|:|:||.||.||:..:.:::|:||:.|||:...|:.
Mouse   436 PSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLLC 500

  Fly   486 LYVLILALRR 495
            :..|...:.:
Mouse   501 VVTLTFIITK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	124/448 (28%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	105/315 (33%)
Ugt2a3	NP_082370.2	UDPGT	25..526	CDD:278624	148/530 (28%)
Ugt2a3	NP_082370.2	egt	<268..507	CDD:223071	93/242 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810