DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_038948318.1	Gene:	Ugt2a1 / 63867	RGDID:	69432	Length:	528	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	166/541 - (30%)
Similarity:	266/541 - (49%)	Gaps:	61/541 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKKIALFLIIWSCGT---LAADILMATQGGTKSHKIPFWELAKGLISRGHNIT--------FLS 54
            |:||:...||.....|   |:.::::....|  ||.:....|.:.|:.|.|::|        |::
  Rat     1 MIKKVLQLLIFPLALTEIVLSGNVVIWPSDG--SHWLNIKILLEELVQRNHSVTVLAASETLFIN 63

  Fly    55 GFPADF-NIEGL-LEVTPAGLVEYI-HNYTNWDLLGSRMAGEMPIKPW------DGLRYAF---- 106
            ..|..| :.|.: :..|.:.:.|.| |....|  |..|   ..|:..|      ..|..||
  Rat    64 SSPDAFISFEEIPVSYTRSKIDEMIEHMIALW--LDHR---PTPLTMWAFYKELGKLFAAFYKIN 123

  Fly   107 -ESCDAMLRDSE-TKELTKKSFDLAILDGAFPECFLGLMYDFK--IPFMY------INTVGFYTG 161
             :.||.:|:::. ...|.|..||:.|.|   |....|.:...|  |||:|      ..||..:.|
  Rat   124 KQICDGVLKNATLMARLQKGGFDVLISD---PVTMCGELVALKLGIPFVYTLRFSPAFTVERHCG 185

  Fly   162 SISTAGNPVSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPH 226
            .|.|   ||||  .|...|..||.|...||..||   |..:|.. |:.:........:....:..
  Rat   186 KIPT---PVSY--VPAALSELTDQMTFGERVKNT---ISYSLQD-YIFKSYWGEWNSYYSRVLGR 241

  Fly   227 P---YEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYV 288
            |   .|........|...:....:||.:.||...|..:||:||:.||:.:|||:..||..|.:..
  Rat   242 PTTLCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFVQTSGEHGVVVF 306

  Fly   289 SMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKL 353
            |:||.||  |:.|...:::....|::|..|||:|:|...  ..:.||.:|..|:||.|:|||||.
  Rat   307 SLGSMVK--NLTEEKANLIASALAQIPQKVLWRYKGKIP--ATLGSNTRLFDWIPQNDLLGHPKT 367

  Fly   354 RAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVI 418
            |||:||||...::|.:|||:|:|.:|:|.|...|.|..:..|.|:::::.|:::..|..|:..||
  Rat   368 RAFITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSADLLSAVRAVI 432

  Fly   419 HNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYL 483
            :.|.|:.:|....::..||....||.|::|.|:|:||.||.||:..:.:::|:||:.|||:...|
  Rat   433 NEPFYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLL 497

  Fly   484 -ILLYVLILALRRIDFPYEKV 503
             .:...::|.::...|.::|:
  Rat   498 ACMASAILLVIKCCLFVFQKI 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	135/439 (31%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	106/309 (34%)
Ugt2a1	XP_038948318.1	UDPGT	22..524	CDD:278624	159/520 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm44525
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810