Protein Alignment Ugt50B3 and UGT2A2

DIOPT Version :9

• Sequence 1: NP_001260710.1
• Gene: Ugt50B3 / 246614
• FlyBaseID: FBgn0050438
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001099147.2
• Gene: UGT2A2 / 574537
• HGNCID: 28183
• Length: 536
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 166/563 - (29%)
• Similarity: 262/563 - (46%)
• Gaps: 110/563 - (19%)

  Fly    17 LAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSG-----------FPADF---------- 60
            |:.::|:....|  ||.:....:.:.||.|.||:|.|:.           .|.:|
Human    28 LSGNVLIWPTDG--SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKS 90

  Fly    61 NIEGLLEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAF----------------ESC 109
            ||:.|:|          |....|  :..|   ..|:..|     ||                :.|
Human    91 NIDSLIE----------HMIMLW--IDHR---PTPLTIW-----AFYKELGKLLDTFFQINIQLC 135

  Fly   110 DAMLRDSE-TKELTKKSFDLAILDGAFPECFLGLMYDFK--IPFMY------INTVGFYTGSIST 165
            |.:|::.: ...|.|..||:.:.|   |....|.:...|  |||||      .:||..:.|.|..
Human   136 DGVLKNPKLMARLQKGGFDVLVAD---PVTICGDLVALKLGIPFMYTLRFSPASTVERHCGKIPA 197

  Fly   166 AGNPVSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEM 230
               ||||  .|...|..||.|...||..||   |..:|.. |:.:........:....:..|..:
Human   198 ---PVSY--VPAALSELTDQMTFGERIKNT---ISYSLQD-YIFQSYWGEWNSYYSKILGRPTTL 253

  Fly   231 SRNVSFILQNGHAVL---------SYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFI 286
            ...:      |.|.:         .:||.:.||...|..:||:||:.||:.:||||.:||.:|.:
Human   254 CETM------GKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKNGVV 312

  Fly   287 YVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHP 351
            ..|:||.||  |:.|...:::....|::|..|||:|:|...  ..:.:|.:|..|:||.|:||||
Human   313 VFSLGSMVK--NLTEEKANLIASALAQIPQKVLWRYKGKKP--ATLGNNTQLFDWIPQNDLLGHP 373

  Fly   352 KLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMK 416
            |.:||:||||...::|.:|||||:|.:|:|.|...|.|..:..|.|::::|.|:::..|..|:..
Human   374 KTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRT 438

  Fly   417 VIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAV 481
            ||:.|.|:.:|....::..||....||.|::|.|:|:||.||.||:..:.::||:||:.|||:..
Human   439 VINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGF 503

  Fly   482 YLILLYVLI-LALRRIDFPYEKVRSLYSLMAPFITIAKTKSKK 523
            .|:.:...| |.::...|..:|          |..|.|.|.::
Human   504 LLVCVTTAIFLVIQCCLFSCQK----------FGKIGKKKKRE 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	134/460 (29%)
		egt	<172..479	CDD:223071	108/315 (34%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	160/537 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm40389
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.810