DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001034638.1	Gene:	Ugt1a5 / 574523	RGDID:	1583689	Length:	531	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	142/521 - (27%)
Similarity:	235/521 - (45%)	Gaps:	69/521 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IALFLIIWSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLS--------------- 54
            :.|:.:.|:.|   ..:|:....|  ||.:...::.:.|.:|||....|:
  Rat    15 LLLYALPWAEG---GKVLVFPMEG--SHWLSMRDVVRELHARGHQAVVLAPEVTVHIKEEDFFTL 74

  Fly    55 -GFPADFNIEGLLE--VTPAGLVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAMLRD- 115
             .:|..:..:|..:  :....:|....||....|..|.:...:.       .....||..:|.:
  Rat    75 QTYPVPYTRQGFRQQMMRNIKVVFETGNYVKTFLETSEILKNIS-------TVLLRSCMNLLHNG 132

  Fly   116 SETKELTKKSFDLAILDGAFPEC------FLGLMYDFKIPFMYINTVGFYTGSISTAGNPVSYAI 174
            |..:.|...|||:.:.|...| |      :||:...|   |:.....|. ....:....|.||
  Rat   133 SLLQHLNSSSFDMVLTDPVIP-CGAVLAKYLGIPTVF---FLRYIPCGI-DSEATQCPKPSSY-- 190

  Fly   175 TPNFYSRFTDTMNLYERAINTAMQIG-QTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVSFI- 237
            .||..:..:|.|...:|..|....:. :.:.|....|      .|.|.:::     :.|.||.:
  Rat   191 IPNLLTMLSDHMTFLQRVKNMLYPLALKYICHFSFTR------YESLASEL-----LQREVSLVE 244

  Fly   238 --------LQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSMGSSV 294
                    |..|..|..|||...||:..:..|:|...:.|.:..|.::.|||..|.:..|:||.|
  Rat   245 VLSHASVWLFRGDFVFDYPRPVMPNMVFIGGINCVIKKPLSQEFEAYVNASGEHGIVVFSLGSMV 309

  Fly   295 KAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTH 359
              :.:||.....:.:...|:|..|||:|.|  |...::..|..|.:||||.|:|||||.|||:||
  Rat   310 --SEIPEKKAMEIAEALGRIPQTVLWRYTG--TRPSNLAKNTILVKWLPQNDLLGHPKARAFITH 370

  Fly   360 GGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYR 424
            .|...::|.:.:|||:|.||:|.|...|:.:.|..|..:.|::..::|:.|..|:..||:|..|:
  Rat   371 SGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYK 435

  Fly   425 NSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLILLYVL 489
            .:......|..|:....||.|::|.|||:||.||.||:..:.::||:||:.|||:...|.::..:
  Rat   436 ENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTV 500

  Fly   490 I 490
            :
  Rat   501 V 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	115/440 (26%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	103/316 (33%)
Ugt1a5	NP_001034638.1	UDPGT	26..522	CDD:278624	139/507 (27%)
Ugt1a5	NP_001034638.1	egt	<259..505	CDD:223071	89/247 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm44525
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810