DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	545	Identity:	156/545 - (28%)
Similarity:	247/545 - (45%)	Gaps:	95/545 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKKIALFLIIWSCGTLAADILMATQGGTKSHKIPFWE----LAKGLISRGHNITFL--SGFPA- 58
            :||...|.||.....|.|.::|:..  |..||    |:    :...|::|.|.:|.|  |..|.
Zfish     5 LLKPSPLVLIFIFSFTHAGNVLVLP--GEYSH----WQNMRNVVDELLNRNHTVTVLVCSASPTI 63

  Fly    59 DF------------------NIEGLLEVTPAGLVEYIHNYTNW-------------DLLGSRMAG 92
            :|                  .::|..|       |.||.:|..             :|||.
Zfish    64 NFTQQERFQYLVFEVPLSAQELDGASE-------ELIHIWTQHPSPNRLQTALQIIELLGR---- 117

  Fly    93 EMPIKPWDGLRYAFES-CDAMLR-DSETKELTKKSFDLAILDGAFPEC------FLGLMYDFKIP 149
                     :|....: ||:||| |:...:|:...||:...|..| .|      .|||.....:.
Zfish   118 ---------VRVMHRAMCDSMLRNDALIAQLSALKFDVLFNDPMF-MCADLLAEMLGLPLVLSVR 172

  Fly   150 FMYINTVGF----YTGSISTAGNPVSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMR 210
            .    :.||    ..|.:     |...:..|...:..||.|...||..|....|..: :..|::.
Zfish   173 I----SPGFCLERMCGQM-----PAPPSFVPITQTVLTDRMCFMERVQNMIANIVFS-VSFYIVA 227

  Fly   211 RTHL--VMREHLGTQIPHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNL 273
            ...|  ...:.||........|.:...::::. :....|||.|.||...|..:||:||:.|.:.:
Zfish   228 WISLDSYYTDVLGKPTTMCETMGKADIWLIRT-YWDFEYPRPFPPNFKFVGGLHCKPAKPLSKEM 291

  Fly   274 EEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKL 338
            |||:.:||..|.:..|:||.:|  |:.....:.:.....::|..|:|:|.|.:.:  .:..|.|:
Zfish   292 EEFVQSSGDHGVVVFSLGSMIK--NLTSERANTIAAALGQIPQKVVWRYSGKTPE--TLAPNTKI 352

  Fly   339 SRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQ 403
            ..|:||.|:|||||.:||:||||...::|.:|||||:|.:|:|.|...|....:..|.|:.||:.
Zfish   353 YDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDIN 417

  Fly   404 TLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNM 468
            ||.:..|..|:..|::||.|:.|.....::..||....||.|:||.|:|:|:.||.||:..:..:
Zfish   418 TLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHEL 482

  Fly   469 TWWQYYLLDVVAVYLILLYVLILAL 493
            :|:||:.|| ||.:|:.:..||..|
Zfish   483 SWYQYHCLD-VAAFLLSIAALITFL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	123/457 (27%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	101/308 (33%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	149/527 (28%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	84/235 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.810