DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and ugt8

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001037790.2	Gene:	ugt8 / 553508	ZFINID:	ZDB-GENE-060616-129	Length:	541	Species:	Danio rerio

Alignment Length:	539	Identity:	168/539 - (31%)
Similarity:	263/539 - (48%)	Gaps:	73/539 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LFLIIWSCGT---LAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNIEGLLEV 68
            |..::|...|   .||.|::......:||...|..||..|.:.||:..||..       || .|:
Zfish     7 LATLLWCLATSLSWAAKIVVVPPIMFESHLYIFKTLASALHAEGHDTVFLVS-------EG-REI 63

  Fly    69 TPAG---LVEY--IHNYTNW-DLLGSRM----AGEM-PIKPWDGLRYAFESCDAMLRDSETKE-L 121
            .|:.   |..|  |.|.|:. |.|.|::    :|.: .::.:|.|.:..::|||::..:...| |
Zfish    64 PPSNHYRLQRYPGIFNSTSADDFLQSKVRNIFSGRLTALELFDILDHYSQNCDAVVGSTSVMEQL 128

  Fly   122 TKKSFDLAILD-----GAFPECFLGLMYD-FKIPFMYINTVGFYTGSISTAGNPVSYAITPNFYS 180
            .::.|||.::|     |......||:.|. |.....|...||        |..|:||  .|.|.|
Zfish   129 KREHFDLLLVDPNEMCGFVIAHILGVQYAVFSTGLWYPAEVG--------APAPLSY--VPEFNS 183

  Fly   181 RFTDTMNLYERAINTAMQ-IGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVSF--ILQNGH 242
            ..||.|:|::|..|||:. :.:..:...|:.:...:||:         |.:..:||.  ::||..
Zfish   184 LLTDHMSLFQRVANTAVYLVSRFGVQFLVLPKYDRIMRK---------YNIQPSVSMHDLVQNSR 239

  Fly   243 -------AVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMP 300
                   ..|.:||...|:|..|..|..:|...||:..|.::..:...||:.||.|:.||  .:.
Zfish   240 LWMLCTDMALEFPRPTLPHVVYVGGILTKPPSPLPQEFETWVKDTDEDGFVVVSFGAGVK--YLS 302

  Fly   301 EALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSM 365
            :.:...|....:|||..|:|::.|  ....::.:|.||..|:||.|:||....|||::||||.|:
Zfish   303 DDIAQKLAGALSRLPQRVIWRFSG--VPPSNLGNNTKLVDWMPQNDLLGQTNTRAFLSHGGLNSI 365

  Fly   366 FETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHR 430
            :|.:|||||||.:|:|.||.....:.:..|..|.|:.:.:|...||.|::.||.:.|||..|:..
Zfish   366 YEAMYHGVPVVGVPLFGDHYDTMTRVQAKGMGIMLEWKRMSEEDLYTAMVNVITDKRYRERAQLL 430

  Fly   431 QKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLD---VVAVYLILL-YVLIL 491
            .::..||....:..|:||..|:|||.||.||::....:..:||:|||   |:.|.|:|. |.|..
Zfish   431 SQIHKDQPGHPVSRAVYWISYILRHRGAEHLRSAVYEIPTYQYFLLDVAMVIGVCLLLTGYCLYR 495

  Fly   492 ALRRIDF-------PYEKV 503
            .::.|.|       |.|||
Zfish   496 IVKFIQFRLGRGSSPGEKV 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	132/433 (30%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	105/319 (33%)
ugt8	NP_001037790.2	UDPGT	22..500	CDD:330975	158/508 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20715
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2881
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.840