Protein Alignment Ugt50B3 and UGT1A3

DIOPT Version :10

• Sequence 1: NP_724417.3
• Gene: Ugt50B3 / 246614
• FlyBaseID: FBgn0050438
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 137/503 - (27%)
• Similarity: 232/503 - (46%)
• Gaps: 55/503 - (10%)

  Fly    31 SHKIPFWELAKGLISRGHNITFLSGFPADFNIEGLLEVTPAGLVEYIHNYTNWDLLGSRMAG--E 93
            ||.:...|:.:.|.:|||....|:   .:.|:. :.|.....|..|..::|. |.....:.|  :
Human    39 SHWLSMREVLRELHARGHQAVVLT---PEVNMH-IKEENFFTLTTYAISWTQ-DEFDRHVLGHTQ 98

  Fly    94 MPIKPWDGLRYAF--------------ESCDAML-RDSETKELTKKSFDLAILDGAFPECFLGLM 143
            :..:....|:..|              .||..:| .::..:.|...|||:.:.|.      :.|.
Human    99 LYFETEHFLKKFFRSMAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDP------VNLC 157

  Fly   144 YDFKIPFMYINTVGFYTGSI--------STAGNPVSYAITPNFYSRFTDTMNLYERAINTAMQIG 200
            ......::.|.|| |:..:|        :...||.||  .|...:..:|.|...:|..|....:.
Human   158 AAVLAKYLSIPTV-FFLRNIPCDLDFKGTQCPNPSSY--IPRLLTTNSDHMTFMQRVKNMLYPLA 219

  Fly   201 QT-LMHM----YVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVAC 260
            .: :.|.    |....:.|..||      ....::..:.|..|..|..|:.|||...||:..:..
Human   220 LSYICHAFSAPYASLASELFQRE------VSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGG 278

  Fly   261 IHCRPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGS 325
            |:|...:.|.:..|.:|.|||..|.:..|:||.|  :.:||.....:.....::|..|||:|.|
Human   279 INCANRKPLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTG- 340

  Fly   326 STDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAK 390
             |...::.:|..|.:||||.|:||||..|||:||.|...::|::.:|||:|.||:|.|...|:.:
Human   341 -TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKR 404

  Fly   391 AEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRH 455
            .|..|..:.|::..:::..|..|:..||::..|:.:......|..|:....||.|::|.|:|:||
Human   405 METKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRH 469

  Fly   456 NGAYHLQTPSRNMTWWQYYLLDVVAVYL-ILLYVLILALRRIDFPYEK 502
            .||.||:..:.::||:||:.|||:...| ::|.|..:..:...:.|.|
Human   470 KGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRK 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_724417.3	Glycosyltransferase_GTB-type	43..480	CDD:471961	129/466 (28%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	137/503 (27%)