Protein Alignment Ugt50B3 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_001260710.1
• Gene: Ugt50B3 / 246614
• FlyBaseID: FBgn0050438
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 140/512 - (27%)
• Similarity: 235/512 - (45%)
• Gaps: 56/512 - (10%)

  Fly    21 ILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNI----EGLLEVTPAG--------- 72
            :::.|.|   ||.:...|..:.|.:|||.:..|:   .:.|:    |....:|...
Human    32 LVVPTDG---SHWLSMREALRDLHARGHQVVVLT---LEVNMYIKEENFFTLTTYAISWTQDEFD 90

  Fly    73 --LVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAML-RDSETKELTKKSFDLAILDGA 134
              |:.:..::...:.|..:.:..|.|.....| ....||..:| .::..:.|...|||:.:.| .
Human    91 RLLLGHTQSFFETEHLLMKFSRRMAIMNNMSL-IIHRSCVELLHNEALIRHLHATSFDVVLTD-P 153

  Fly   135 FPECFLGLMYDFKIPFMYINTVGFYTGSI--------STAGNPVSYAITPNFYSRFTDTMNLYER 191
            |..|...|.....||.:      |:..:|        :...||.||  .|...:..:|.|...:|
Human   154 FHLCAAVLAKYLSIPAV------FFLRNIPCDLDFKGTQCPNPSSY--IPRLLTTNSDHMTFLQR 210

  Fly   192 AINTAMQIGQT-LMHM----YVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNGHAVLSYPRAF 251
            ..|....:..: |.|.    |....:.|..||      ....::..:.|..|..|..|:.|||..
Human   211 VKNMLYPLALSYLCHAVSAPYASLASELFQRE------VSVVDLVSHASVWLFRGDFVMDYPRPI 269

  Fly   252 NPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPY 316
            .||:..:..|:|...:.|.:..|.:|.|||..|.:..|:||.|  :.:||.....:.....::|.
Human   270 MPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQ 332

  Fly   317 HVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVF 381
            .|||:|.|  |...::.:|..|.:||||.|:||||..|||:||.|...::|::.:|||:|.||:|
Human   333 TVLWRYTG--TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLF 395

  Fly   382 CDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAI 446
            .|...|:.:.|..|..:.|::..:::..|..|:..||::..|:.:......|..|:....||.|:
Human   396 GDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAV 460

  Fly   447 YWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYL-ILLYVLILALRRIDFPYEK 502
            :|.|:|:||.||.||:..:.::||:||:.|||:...| ::|.|..:..:...:.|.|
Human   461 FWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRK 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	112/434 (26%)
		egt	<172..479	CDD:223071	98/311 (32%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	140/512 (27%)
		egt	<262..508	CDD:223071	87/249 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm40389
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910