Protein Alignment Ugt50B3 and UGT1A5

DIOPT Version :10

• Sequence 1: NP_724417.3
• Gene: Ugt50B3 / 246614
• FlyBaseID: FBgn0050438
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 140/512 - (27%)
• Similarity: 235/512 - (45%)
• Gaps: 56/512 - (10%)

  Fly    21 ILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNI----EGLLEVTPAG--------- 72
            :::.|.|   ||.:...|..:.|.:|||.:..|:   .:.|:    |....:|...
Human    32 LVVPTDG---SHWLSMREALRDLHARGHQVVVLT---LEVNMYIKEENFFTLTTYAISWTQDEFD 90

  Fly    73 --LVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAML-RDSETKELTKKSFDLAILDGA 134
              |:.:..::...:.|..:.:..|.|.....| ....||..:| .::..:.|...|||:.:.| .
Human    91 RLLLGHTQSFFETEHLLMKFSRRMAIMNNMSL-IIHRSCVELLHNEALIRHLHATSFDVVLTD-P 153

  Fly   135 FPECFLGLMYDFKIPFMYINTVGFYTGSI--------STAGNPVSYAITPNFYSRFTDTMNLYER 191
            |..|...|.....||.:      |:..:|        :...||.||  .|...:..:|.|...:|
Human   154 FHLCAAVLAKYLSIPAV------FFLRNIPCDLDFKGTQCPNPSSY--IPRLLTTNSDHMTFLQR 210

  Fly   192 AINTAMQIGQT-LMHM----YVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNGHAVLSYPRAF 251
            ..|....:..: |.|.    |....:.|..||      ....::..:.|..|..|..|:.|||..
Human   211 VKNMLYPLALSYLCHAVSAPYASLASELFQRE------VSVVDLVSHASVWLFRGDFVMDYPRPI 269

  Fly   252 NPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPY 316
            .||:..:..|:|...:.|.:..|.:|.|||..|.:..|:||.|  :.:||.....:.....::|.
Human   270 MPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQ 332

  Fly   317 HVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVF 381
            .|||:|.|  |...::.:|..|.:||||.|:||||..|||:||.|...::|::.:|||:|.||:|
Human   333 TVLWRYTG--TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLF 395

  Fly   382 CDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAI 446
            .|...|:.:.|..|..:.|::..:::..|..|:..||::..|:.:......|..|:....||.|:
Human   396 GDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAV 460

  Fly   447 YWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYL-ILLYVLILALRRIDFPYEK 502
            :|.|:|:||.||.||:..:.::||:||:.|||:...| ::|.|..:..:...:.|.|
Human   461 FWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRK 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_724417.3	Glycosyltransferase_GTB-type	43..480	CDD:471961	130/465 (28%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	140/512 (27%)