DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and UGT1A10

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_061948.1	Gene:	UGT1A10 / 54575	HGNCID:	12531	Length:	530	Species:	Homo sapiens

Alignment Length:	522	Identity:	151/522 - (28%)
Similarity:	244/522 - (46%)	Gaps:	53/522 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IIWSCG-TLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFP-ADFNIEGLLEVTPAG 72
            ::.:|| ..|..:|:....|  ||......:.:.||.|||.:..:  .| ..:.:|..|..|
Human    16 LLLTCGFAEAGKLLVVPMDG--SHWFTMQSVVEKLILRGHEVVVV--MPEVSWQLERSLNCT--- 73

  Fly    73 LVEYIHNYT--------------NW--------DLLGSRMAGEMPIKPWDGLRYAFESCDAMLRD 115
            :..|..:||              .|        .||.|..:|.:.:        .|..|.::..|
Human    74 VKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDL--------FFSHCRSLFND 130

  Fly   116 SETKE-LTKKSFDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSISTAGN---PVSYAITP 176
            .:..| |.:.|||...|| .|..|.|.:...|.:|.: :.|.|.:...:.....   |:||  .|
Human   131 RKLVEYLKESSFDAVFLD-PFDTCGLIVAKYFSLPSV-VFTRGIFCHHLEEGAQCPAPLSY--VP 191

  Fly   177 NFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNG 241
            |....|:|.|...||..|..:.:...|...|:.|....:..|.|.|.:. .|::..:.|..|...
Human   192 NDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVT-AYDLYSHTSIWLLRT 255

  Fly   242 HAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEALRHM 306
            ..||.||:...||:..:..|:|...:.||...|.:|.|||..|.:..|:||.|  :.:||.....
Human   256 DFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMA 318

  Fly   307 LVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYH 371
            :.....::|..|||:|.|  |...::.:|..|.:||||.|:||||..|||:||.|...::|::.:
Human   319 IADALGKIPQTVLWRYTG--TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICN 381

  Fly   372 GVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLD 436
            |||:|.||:|.|...|:.:.|..|..:.|::..:::..|..|:..||::..|:.:......|..|
Human   382 GVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKD 446

  Fly   437 QRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYL-ILLYVLILALRRIDFPY 500
            :....||.|::|.|:|:||.||.||:..:.::||:||:.|||:...| ::|.|..:..:...:.|
Human   447 RPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGY 511

  Fly   501 EK 502
            .|
Human   512 RK 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	121/432 (28%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	102/306 (33%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	148/512 (29%)
UGT1A10	NP_061948.1	egt	<258..504	CDD:223071	88/249 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm40389
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.810