Protein Alignment Ugt50B3 and UGT1A10

DIOPT Version :10

• Sequence 1: NP_724417.3
• Gene: Ugt50B3 / 246614
• FlyBaseID: FBgn0050438
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 151/522 - (28%)
• Similarity: 244/522 - (46%)
• Gaps: 53/522 - (10%)

  Fly    10 IIWSCG-TLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFP-ADFNIEGLLEVTPAG 72
            ::.:|| ..|..:|:....|  ||......:.:.||.|||.:..:  .| ..:.:|..|..|
Human    16 LLLTCGFAEAGKLLVVPMDG--SHWFTMQSVVEKLILRGHEVVVV--MPEVSWQLERSLNCT--- 73

  Fly    73 LVEYIHNYT--------------NW--------DLLGSRMAGEMPIKPWDGLRYAFESCDAMLRD 115
            :..|..:||              .|        .||.|..:|.:.:        .|..|.::..|
Human    74 VKTYSTSYTLEDQNREFMVFAHAQWKAQAQSIFSLLMSSSSGFLDL--------FFSHCRSLFND 130

  Fly   116 SETKE-LTKKSFDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSISTAGN---PVSYAITP 176
            .:..| |.:.|||...|| .|..|.|.:...|.:|.: :.|.|.:...:.....   |:||  .|
Human   131 RKLVEYLKESSFDAVFLD-PFDTCGLIVAKYFSLPSV-VFTRGIFCHHLEEGAQCPAPLSY--VP 191

  Fly   177 NFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNG 241
            |....|:|.|...||..|..:.:...|...|:.|....:..|.|.|.:. .|::..:.|..|...
Human   192 NDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALEIASEILQTPVT-AYDLYSHTSIWLLRT 255

  Fly   242 HAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEALRHM 306
            ..||.||:...||:..:..|:|...:.||...|.:|.|||..|.:..|:||.|  :.:||.....
Human   256 DFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMA 318

  Fly   307 LVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYH 371
            :.....::|..|||:|.|  |...::.:|..|.:||||.|:||||..|||:||.|...::|::.:
Human   319 IADALGKIPQTVLWRYTG--TRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICN 381

  Fly   372 GVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLD 436
            |||:|.||:|.|...|:.:.|..|..:.|::..:::..|..|:..||::..|:.:......|..|
Human   382 GVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKD 446

  Fly   437 QRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYL-ILLYVLILALRRIDFPY 500
            :....||.|::|.|:|:||.||.||:..:.::||:||:.|||:...| ::|.|..:..:...:.|
Human   447 RPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGY 511

  Fly   501 EK 502
            .|
Human   512 RK 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_724417.3	Glycosyltransferase_GTB-type	43..480	CDD:471961	139/463 (30%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	148/512 (29%)