DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt37E1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_652628.2	Gene:	Ugt37E1 / 53512	FlyBaseID:	FBgn0040261	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	156/541 - (28%)
Similarity:	241/541 - (44%)	Gaps:	76/541 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLIIWSCGTL-----AADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADF----NIE 63
            |||.:...|:     .|:||......:.||.|....:.|.|..||||||.::......    ||.
  Fly     9 FLIAFLLSTMTQSSGGANILGVFGTHSPSHVIVHMAVMKALADRGHNITVVTQMKPKLATHENIT 73

  Fly    64 GLLEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAMLRD----------SET 118
            .::.........||..|.      :.::.|.| ..|:.:..|.......|..          .|.
  Fly    74 VIIAPPTEERQRYIKEYM------AEVSNEKP-SFWETMVKAIVQSSNQLEGQYEFMTHPNVKEI 131

  Fly   119 KELTKKSFDLAILDGAFPECF-LGLMYDFK---------IPFMYINTVGFYTGSISTAGNPVSYA 173
            .|..|..|||..| |.....: ||:....|         ||..:::|:   .|::    |..||.
  Fly   132 YENPKIKFDLVFL-GLMANTYQLGIAAKLKCPVIISWVGIPLPFMDTI---VGNV----NDPSYV 188

  Fly   174 ITPN-----------FYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHP 227
            .|.|           |..||   :|.::.||   |.:.:|::...:.:.........|  :.|:.
  Fly   189 PTVNVALNAGQKTMDFGLRF---VNFFKYAI---MCVFETVLDYKMNQFYERAFANEL--EFPNY 245

  Fly   228 YEMSRNVSFILQNGHAVLSYP-RAFNPNVAEVACIHCR-PARKLPRNLEEFIGASGASGFIYVSM 290
            :||.|.||.:..|.|:....| |...|...|:..|..: .|..||:.|.:|:..:. .|.|:.|:
  Fly   246 HEMKRRVSLLFYNYHSASEGPIRPTVPQSIEIGGIQVKEQADPLPKELAKFLDKAD-EGAIFFSL 309

  Fly   291 GSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKD---ITSNVKLSRWLPQQDILGHPK 352
            |::|...........:|.|..::||..|:||:|    |:|:   ..||:....||||.|||.||.
  Fly   310 GTNVNTNTFRPDTVDILYKVLSKLPQRVIWKWE----DLKNKPGNASNIFFGNWLPQDDILAHPN 370

  Fly   353 LRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKV 417
            .:.|:||.|...:.|..|||||:|.:|:|.|...|:......|:...||:.|::.::|.:.|.:|
  Fly   371 TKLFITHAGKGGVAEAQYHGVPMVALPIFGDQQGNAEIMTKSGFGRWLDILTMTEHELEQTIREV 435

  Fly   418 IHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVY 482
            :.||.||.:......|:.|:..||..:.||||||||||.||.|||:|..:..:.....|||..|.
  Fly   436 LGNPAYRETIGKFSTLYRDRPLTARQSVIYWTEYVLRHQGALHLQSPLIHTKFVARNNLDVYGVV 500

  Fly   483 LILLYVLILALRRIDFPYEKV 503
            |::..:||:.::   |.:.|:
  Fly   501 LLVSLLLIVTIK---FLFRKI 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	120/445 (27%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	104/322 (32%)
Ugt37E1	NP_652628.2	egt	7..475	CDD:223071	141/493 (29%)
Ugt37E1	NP_652628.2	YjiC	27..448	CDD:224732	122/448 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	6	6.020