DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt302C1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	168/521 - (32%)
Similarity:	267/521 - (51%)	Gaps:	55/521 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IALFLI-IWSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGF------------ 56
            :||.|. :.|| ..|.:.|:......:||......|||||.:.||.:|.:|.|
  Fly    11 LALLLFCLLSC-VSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKPIKNIKDV 74

  Fly    57 PA-------DFNIEGLLEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAMLR 114
            ||       ...|..||:.:...:::.|.|:           .||.|          |..:.:|:
  Fly    75 PAKSILTSMQGRIANLLQSSKEPIIKQIINF-----------HEMGI----------EITELLLK 118

  Fly   115 DSETKELTK--KSFDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSISTAGNPVSYAITPN 177
            :....||.|  ::||..|.:....|...|....||.|.:.:.|.|..:.:....|:|...:..|:
  Fly   119 EPSVIELMKSNQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNTDLVGSPSPPSYVPS 183

  Fly   178 FYSRFTDTMNLYERAINTA-MQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNG 241
            ...:|:|.|:|.||..|.| :......::.:.:.|..::.|::........|:|.:|.:.:|.|.
  Fly   184 ALLKFSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFYDMRKNTALVLLNQ 248

  Fly   242 HAVLSYPRAFNPNVAEVACIHC-RPARKLPRNLEEFIGASGAS-GFIYVSMGSSVKAANMPEALR 304
            |..||:||.::||:.||..:|. |..:.||:::.|||  .||. |.||.||||::|:..:|...|
  Fly   249 HVSLSFPRPYSPNMIEVGGMHINRKRQPLPKDILEFI--EGAEHGVIYFSMGSNLKSKTLPLEKR 311

  Fly   305 HMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETV 369
            ..|:.|||:|...||||:|  .||:....:||.:|.|.||.|||.|..:.||:|||||||..|::
  Fly   312 QALIDTFAQLKQRVLWKFE--DTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESI 374

  Fly   370 YHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLF 434
            ||..|.|.:|:|.|..:|.|:||.:||.:.:..:.||:.:|..||.|:|:||......|.....:
  Fly   375 YHRKPFVGIPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRY 439

  Fly   435 LDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAV----YLILLYVLILALRR 495
            .||:.|.|:.|:||.|:|.||.||.:|::.|:::.:.||:.||.:.:    .:.:||.:.|.:|.
  Fly   440 RDQQQTPLERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLILYGGIIFVLYCIFLLIRL 504

  Fly   496 I 496
            :
  Fly   505 V 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	138/429 (32%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	118/309 (38%)
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	128/352 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.678979	Normalized mean entropy	S5661
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.870