DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt35E2

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	151/530 - (28%)
Similarity:	248/530 - (46%)	Gaps:	91/530 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 HKIPFWELAKGLISRGHNITFLSGFPADFNIEGLLEVTPAGLV----EYIHNYTNWDLLGSRMAG 92
            |.:|:   .|.|.|.||.||.:|.||....:..:.::....|.    |.:.|.||       ..|
  Fly    41 HALPY---LKKLASLGHEITSVSPFPLKEPVANIHDIPVPELFDNIEEIVGNLTN-------RKG 95

  Fly    93 EMPIKPWDGLRYAFESCDAML-----RDSETKELTKK---SFDLAILDGAFPECFLGLMYDFKIP 149
                 .|:...|..:....::     .|...:|:.:.   .|||.|:|....:...||...|..|
  Fly    96 -----TWNEFEYINQYTLGLVEKVLENDGVRREILQPESLQFDLIIVDLWRLDALYGLAAYFDAP 155

  Fly   150 FMYINTVGF------YTGSISTAGNPVSYAITPNF-----------YSRFTDTMNLYERAINTAM 197
            .:.|.:.|.      ..|::|    |::|..:|:|           ...|.|....:   ||
  Fly   156 IIGIASYGTDWKIDELVGNVS----PLAYLQSPSFNWFDLDTYGGRLGHFVDQSMAW---IN--- 210

  Fly   198 QIGQTLMHMYVMRRTHLVMREHLGTQIPHP--------YEMSRNVSFILQNGHAVLSYPRAFNPN 254
                  .|.....|...|.|::.      |        .|::||.:.||.|.|..::.||.:.||
  Fly   211 ------WHWRHEERHEAVYRKYF------PKIADKRSLSEITRNFALILVNQHFTMAPPRPYVPN 263

  Fly   255 VAEVACIHC-RPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPYHV 318
            :.||..:|. :..:.||::||:||..:|..|.||.|:|::|::.|:.:..|.:|:.|||.||..:
  Fly   264 IIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDRRKILIDTFASLPQRI 328

  Fly   319 LWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCD 383
            |||::  :.::.|:.|||.:|.|.||||||.||.::.|:|||||.|..|.::.|||::.:|.|.|
  Fly   329 LWKFD--ADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIHRGVPMLGLPFFYD 391

  Fly   384 HDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYW 448
            ...|....:..|..:.|:.:.:::::....|.:::....:...|:.....:.||....|||||:|
  Fly   392 QFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYRDQPMNPLDTAIWW 456

  Fly   449 TEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLILLYVLILALRRIDFPYEKVRSLYSLMAPF 513
            |.|||||.||.|::...||:.:..|:.|||:..:|:.::.::              |:..|.|..
  Fly   457 THYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAIL--------------SIVVLCAIK 507

  Fly   514 ITIAKTKSKK 523
            :..|..||||
  Fly   508 LLRAILKSKK 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	119/439 (27%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	105/326 (32%)
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	138/478 (29%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	119/437 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.920