DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt35E1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_652622.3	Gene:	Ugt35E1 / 53504	FlyBaseID:	FBgn0040253	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	154/514 - (29%)
Similarity:	261/514 - (50%)	Gaps:	45/514 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 HKIPFWELAKGLISRGHNITFLSGFPADFNIEGLLEVTPAGLVEYIHNYTN-WDLLGSRMAGEMP 95
            |.:|:   .|.|.|.||.||.:|.||::..::.:.::       |:....| :|.|..:|.  .|
  Fly    37 HALPY---LKNLASLGHEITSVSPFPSEEPVKNIYDI-------YVPEVLNSFDELLKQMT--TP 89

  Fly    96 IKPWDGLRYAFE-----SCDAMLRDSETKELT---KKSFDLAILDGAFPECFLGLMYDFKIPFMY 152
            ...|:......|     :.|....|...:|:.   |..|||.|:|....:.|..|...|:.|.:.
  Fly    90 KNTWEFFDATNEFVYNITKDVFNNDGVRREILRPGKAQFDLIIVDIWKYDAFYSLAAYFEAPIIG 154

  Fly   153 INTVGFYTGSISTAGN--PVSYAITPNFYSRFTDTM-----NLYERAI---NTAMQIGQTLMHMY 207
            :...|.........||  |:||..:|:.|....||.     ::.|.||   |...:..|....:|
  Fly   155 LAPCGIDWKIDEMVGNPSPMSYLQSPSSYLYNLDTFGGRVAHVVEVAISWFNWHWRYEQKHEALY 219

  Fly   208 VMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHC-RPARKLPR 271
            ......:...:.|.       |:|::::.:|.|.|..|..||.:.|||.||..:|. ...:.|.:
  Fly   220 KKYFPKIAETKPLS-------EISQDIALVLVNQHFTLGPPRPYVPNVIEVGGMHIDEQPKALAQ 277

  Fly   272 NLEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNV 336
            :||:||..||..|.||.|:|::|:..||.:..:.:|::.|..||..||||:|  ..:::||.|||
  Fly   278 DLEDFIQGSGEHGVIYFSLGTNVRTKNMVDDRKRILIEAFGSLPQRVLWKFE--DEELQDIPSNV 340

  Fly   337 KLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLD 401
            .:.:||||||:|.|||::.|:||||:.|..|::::|.|::.:|.|.|...|....:..|:.:.|:
  Fly   341 LVRKWLPQQDLLAHPKVKLFITHGGMQSTIESIHYGKPMLGLPFFYDQFTNVDHIKKHGFCLSLN 405

  Fly   402 LQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSR 466
            ...:::::|...|::::...|:..:||.....:.||....|:||::||.|||||.||.|::...|
  Fly   406 YHDMTSDELKATILQLLTEKRFEVTARIAGARYRDQPMKPLETAVWWTHYVLRHKGAPHMRVAGR 470

  Fly   467 NMTWWQYYLLDVV-AVYLILLYVLILALRRIDFPYEKVRSLYSLMAPFITIAKTKSKKI 524
            .::::.::.|||: .|.|::|.|:|..|..|.|...|:....|..   :.:.|.:.:|:
  Fly   471 KLSFFTHHSLDVLGTVLLVILLVIIAILLIIVFSVCKISKNISTR---LVVKKQRKQKV 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	123/421 (29%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	103/315 (33%)
Ugt35E1	NP_652622.3	egt	6..461	CDD:223071	135/444 (30%)
Ugt35E1	NP_652622.3	UDPGT	33..484	CDD:278624	142/467 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.920