DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt303A1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001262470.1	Gene:	Ugt303A1 / 53503	FlyBaseID:	FBgn0040252	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	153/551 - (27%)
Similarity:	254/551 - (46%)	Gaps:	72/551 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKKIALFLIIWSCGTLAADILMA---TQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNI 62
            :|..:.||.::....|.|.:||..   |.|.:.....||   .:.|:.|||.:|.:|......:|
  Fly    10 LLLTVLLFGLLCPKLTNAENILAVFSYTFGSSYLLITPF---LRNLVQRGHQLTLISAVTIMPHI 71

  Fly    63 EGLLEVTPAGL---------VEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAMLRDSET 118
            ||:..:....|         .||..:.|.|  ..::...|          |.:.....:|.|...
  Fly    72 EGVHHIRVPKLDMLMKILLDFEYDTDLTKW--TEAQFLSE----------YFYNCSKFVLEDPGV 124

  Fly   119 KELTKKS---FDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSISTAGNPVSYAITPNFYS 180
            :||.:.:   :.|.||:.:..:...|....|..|.:.:...|.........||.......|....
  Fly   125 QELLRNASAKYSLIILEASHNDALYGFSQHFNAPLLGVAAYGSSWNIDFLVGNSAPSVYEPMSAL 189

  Fly   181 RFTDTMNLYERAINTAMQIGQTLMH--MYVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNGHA 243
            .:|..:||.|:..|......:.|:.  :|:.|:..| .::|........:::.|..|.:|.|.|.
  Fly   190 GYTSGLNLIEKWHNLIYITEERLVERFIYLPRQIDL-YKQHFPGATTSIHDLRRRFSLVLINQHF 253

  Fly   244 VLSYPRAFNPNVAEVACIHC--RP---ARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEAL 303
            .:...|:..||:.|||.:|.  :|   ..:|.:.|:|     ...|.||.|||..:....:|..:
  Fly   254 TMGRVRSNVPNIVEVAGMHLDEKPYPLDAELKKILDE-----AEHGVIYFSMGLQLLDHWLPPGM 313

  Fly   304 RHMLVKTFARLPYHVLWKYEGSSTDIKDITS---NVKLSRWLPQQDILGHPKLRAFVTHGGLLSM 365
            |..:...||:|...|:||     ||..::.:   ||....|.||:.||.||.::.|:||.||||:
  Fly   314 RASMSDAFAQLKQQVIWK-----TDYPEMVNQSRNVFARTWFPQRAILNHPNVKLFITHAGLLSL 373

  Fly   366 FETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHR 430
            .|:|::.||::.:|:|.|...|:.:.|..|.|.|||.:.|..:::..||..:::|..|:.:||..
  Fly   374 IESVHYAVPLLCIPLFYDQFQNTKRMEKLGVARKLDFKNLFRDEIVLAIEDLVYNASYKRNARDL 438

  Fly   431 QKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVY--------LILLY 487
            .:.|.||..:|:||||:||||:|||.||.|::...:.|:..|||.:|||:|.        :|:::
  Fly   439 SQRFHDQPMSAMDTAIWWTEYILRHKGADHMRIAEQEMSLMQYYNVDVVSVLFGRIGLSAIIVIF 503

  Fly   488 ----VLILALRRIDFPYEKVRSLYSLMAPFI 514
                ::.||.|.::         |.|..|.:
  Fly   504 LGWKLVSLATRHLE---------YRLNVPMV 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	111/427 (26%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	103/316 (33%)
Ugt303A1	NP_001262470.1	egt	26..465	CDD:223071	131/464 (28%)
Ugt303A1	NP_001262470.1	UDPGT	39..507	CDD:278624	139/493 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.970