DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt50B3 and Ugt8

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_062149.1	Gene:	Ugt8 / 50555	RGDID:	3938	Length:	541	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	172/526 - (32%)
Similarity:	270/526 - (51%)	Gaps:	50/526 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLIIWSCGTL--AADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNIEGLLEVTP 70
            |:::||...:  ||.|::......:||...|..||..|..|||:..||..       || .::.|
  Rat     8 FMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVFLLS-------EG-RDIDP 64

  Fly    71 A---GLVEY--IHNYTNWD-LLGSRM----AGEM-PIKPWDGLRYAFESCDAML-RDSETKELTK 123
            :   .|..|  |.|.|..| .|.|:|    :|.: .::..|.|.:..::||.|: ..:..:.|.|
  Rat    65 SNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMVGNQALIQGLKK 129

  Fly   124 KSFDLAILDGAFPE--CFLGLMYDFKIPFMYINTVGFYTGSISTAGNPVSYAITPNFYSRFTDTM 186
            :.|||.::|   |.  |...:.:...:.:...:|..:|...:   |.|...|..|.|.|..||.|
  Rat   130 EKFDLLLVD---PNDMCGFVIAHLLGVKYAVFSTGLWYPAEV---GAPAPLAYVPEFNSLLTDRM 188

  Fly   187 NLYERAINTAMQ-IGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNGHAVLSYPRA 250
            |..||..||.:. |.:..:...|:.:...:|:::........|::....|..:......|.:||.
  Rat   189 NFLERMKNTGVYLISRMGVSFLVLPKYERIMQKYNLLPAKSMYDLVHGSSLWMLCTDVALEFPRP 253

  Fly   251 FNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLP 315
            ..|||..|..|..:||..||.:|:.::..:...||:.||.|:.||  .:.|.:.:.|.....|||
  Rat   254 TLPNVVYVGGILTKPASPLPEDLQRWVDGAQEHGFVLVSFGAGVK--YLSEDIANKLAGALGRLP 316

  Fly   316 YHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPV 380
            ..|:|::.|  |..|::.:|.||..||||.|:|||..:|||::||||.|:|||:|||||||.:|:
  Rat   317 QKVIWRFSG--TKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPL 379

  Fly   381 FCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTA 445
            |.||.....:.:..|..|.|:..|::..:||.|::|||:||.||..|:...::..||....::..
  Rat   380 FGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRT 444

  Fly   446 IYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDV--------VAVYLILLYVLILALRRIDFPYEK 502
            .||.:|:|||:||:||::....:::.||:|||:        ||:|.|:.||       ..|.|.|
  Rat   445 TYWIDYILRHDGAHHLRSAVHQISFCQYFLLDIAFVLLLGAVALYFIVSYV-------TKFIYRK 502

  Fly   503 VRSLYS 508
            |:||.|
  Rat   503 VKSLCS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	136/420 (32%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	112/315 (36%)
Ugt8	NP_062149.1	egt	8..490	CDD:223071	161/499 (32%)
Ugt8	NP_062149.1	UDPGT	21..502	CDD:278624	163/505 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20715
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3217
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm44525
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860