DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt36A1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001285591.1	Gene:	Ugt36A1 / 44058	FlyBaseID:	FBgn0015663	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	134/530 - (25%)
Similarity:	232/530 - (43%)	Gaps:	70/530 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIIWSCGTL-------AADILMATQGGTKSHKIPFWELAKGLISRGHNITFLS--------GFP- 57
            |||...|.|       |.:||........||......:...|..|||:||.:|        .:|
  Fly    10 LIIVLLGILGIPEPISAGNILAVYPHFGFSHFKVVMPILNELAHRGHDITVISYVKNPQAGAYPN 74

  Fly    58 ---------------ADFNIEGLLEVTPA-GLVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAF 106
                           ...|:..|.|.||. .|...|..|.:....|.:
  Fly    75 YEELLISAPGEDQSSTTINLVPLTEHTPTRSLGVLIREYVDLHEEGQK----------------- 122

  Fly   107 ESCDAMLRDSETKELTK----KSFDLAILDGAFPECFLGLMYDFKIPFMYINT---VGFYTGSIS 164
             :|:.:......:...:    |.:||.:.:....:|.|.|.....:|.:.::|   :.:|...|.
  Fly   123 -TCEHLFASGHIERAIERHRNKPYDLLLTEYFNSDCQLALAKLLNLPIIGLSTCALMPYYYDRID 186

  Fly   165 TAGNPVSYAITPNFYSRFTDTMNLYERAIN-TAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPY 228
            ....|   |...:.:..|...:|.:||.:| ...::.:.|...:..|..:.::|::||.::....
  Fly   187 LPDTP---AFIQSEFVGFAGQLNWHERLLNFVQAKLLKFLYKYHSNRADNELVRKYLGVEVDVEE 248

  Fly   229 EMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHC--RPARKLPRNLEEFIGASGASGFIYVSMG 291
            ......:||..|.|..|...|..:....|:..:|.  :..::||:|:..|:..| |.|.|::|.|
  Fly   249 VARTQTAFIFGNQHYSLMGSRPQSLQFVEIGGVHITKKAEQELPQNIANFLNQS-AEGVIFISWG 312

  Fly   292 SSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAF 356
            |.|:|:::.|.....:::.....|..::||:|...|...| .|.....:|.||..:|.|||::.|
  Fly   313 SMVRASSIDEDKLSAILEVLKSQPLKIIWKWEADETPDTD-ASKFLFVKWAPQLALLCHPKVKLF 376

  Fly   357 VTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNP 421
            .:|||||...|:|:.|.|::..|::.|..:|:...:..|..:|||.|.::...|.||:.::..|
  Fly   377 WSHGGLLGTTESVHCGKPLLVTPIYGDQFLNAFSVQNRGMGLKLDYQDITVPNLKKALAELSKN- 440

  Fly   422 RYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNG---AYHLQTPSRNMTWWQYYLLDVVAVYL 483
            .|...:....|:|.:::.|.|::||:..|:|: .||   |..||:|...:..:.|:.||.||:.|
  Fly   441 SYAQRSLEVSKVFNERQQTPLESAIWSVEHVI-SNGLIAARLLQSPGIELNGFVYHSLDSVALIL 504

  Fly   484 ILLYVLILAL 493
            :.|.:|||.|
  Fly   505 LPLILLILVL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	102/440 (23%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	87/312 (28%)
Ugt36A1	NP_001285591.1	egt	8..475	CDD:223071	117/489 (24%)
Ugt36A1	NP_001285591.1	UDPGT	38..501	CDD:278624	118/487 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45374
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	7.070