DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt303B1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	138/494 - (27%)
Similarity:	235/494 - (47%)	Gaps:	39/494 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 HKIPFW---ELAKGLISRGHNITFLS--GFPADFNIEGLLEVTPAGLVEYIHNYTNWDLLGSRMA 91
            |..||:   .|.:.|.:||||:|.::  |.|.|  |||:..:..|.|.|.|.     ::|.|...
  Fly    34 HISPFFVMQPLVRTLATRGHNVTLITPIGMPND--IEGVRHIRVAQLNERIK-----EMLESDQV 91

  Fly    92 GEMPIKPWD----GLRYAFESCDAMLRDSETKEL---TKKSFDLAILDGAFPECFLGLMYDFKIP 149
            .:..|..|.    ..:..|.:.:.:|.|...:.:   ..:||||.|::.:..:...||:..:...
  Fly    92 LDFMINKWTESALTAKALFNASNDILSDPGVQRMLHDKSESFDLIIMEPSSLDALYGLVEFYNAT 156

  Fly   150 FMYINTVGFYTGSISTAGNPVSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMYVMRRTHL 214
            .|.::::.....:...||||......|.....|:...:|:.|..|....:.:.|::..::|...|
  Fly   157 LMGLSSIRINWHTYELAGNPAPSIYEPISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQL 221

  Fly   215 -VMREHLGTQIPHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIH-CRPARKLPRNLEEFI 277
             :.::..|.......|:....|.:|.|.|..:...||..||:.||..:| ..|.......|::|:
  Fly   222 HLFQKFFGYSAQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFL 286

  Fly   278 GASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWL 342
            ..:. .|.||.|||:.:....:||.::.:|::|||.|...::||.|  ...:.|.:.||.:....
  Fly   287 DKAD-HGVIYFSMGNDILIKFLPENIQELLLQTFATLNESIIWKSE--LLYMPDKSDNVYVVEQA 348

  Fly   343 PQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSA 407
            ||:.||.||.:|.|:|:|||||:.|.|..|||::.:|:|.|...|....::.|.|..:|:.:|:.
  Fly   349 PQRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNK 413

  Fly   408 NQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQ 472
            :.|.:.|..::.|..|...|:...:.|.|:..:.||||::||||.||:.....::.....:...:
  Fly   414 DTLTETIKHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIE 478

  Fly   473 YYLLD-----------VVAVYLILLYVLIL----ALRRI 496
            ||.:|           |.|..:.|:|.|.|    .|||:
  Fly   479 YYRIDSILAFSLRFGLVAASLIFLVYTLFLKYRIRLRRL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	114/415 (27%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	90/319 (28%)
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	126/437 (29%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	132/479 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.970