DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt303B3

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	145/522 - (27%)
Similarity:	242/522 - (46%)	Gaps:	66/522 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AADILMATQGGTKSHKIPFWELAKGLISRGHNITFLS--GFPADFNIEGLLEVTPAGL----VEY 76
            ||:||........||.:....|||.|:.||||:|.::  |.|.|  |||:..:....|    .|.
  Fly    27 AANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGMPTD--IEGVRHIRVPKLNQRVQEM 89

  Fly    77 IHNYTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAMLRDSETKELTK---KSFDLAILDGAFPEC 138
            |......|..||:....:.:     :...:.....:|.|...:::.:   :.|||.:|:.:..|.
  Fly    90 IEGDQILDFFGSKWIASLMV-----VSMLYNMSSDILSDKGVQKMLQNRNERFDLVMLEPSALEA 149

  Fly   139 FLGLMYDFKIPFMYINTVGFYTGSIS-----TAGN-------PVS---YAITPNFYSRFTDTMNL 188
            ..|::..:....|     ||..|:::     .|||       |:|   |:.:.:..|:..:.:::
  Fly   150 LYGVVEHYNATLM-----GFSGGNVNWSTEEVAGNFAPSINDPISSLGYSRSNSLLSKIYNWVHI 209

  Fly   189 YERAINTAMQIGQTLMHMYVMRRTHL-VMREHLGTQIPHPYEMSRNVSFILQNGHAVLSYPRAFN 252
            .|..:         |.|: :.|.:.| :.::.........|.|....|.||.|.|..:...|:..
  Fly   210 TEEKL---------LKHL-IFRPSQLRIFKKFFNFSEQKFYNMREKYSVILVNNHISMGRVRSNV 264

  Fly   253 PNVAEVACIH-CRPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPY 316
            ||:.||..:| ..||......|::|:. ....|.||.|||..:....:||.::..|:|:..:...
  Fly   265 PNIIEVGGLHLTEPAEPCDSKLQKFMD-DAEHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQ 328

  Fly   317 HVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVF 381
            .|:||.|  ..::.:.:.||.:....||:.:|.||..|.|:|:|||||:.|.||.|||::.:|||
  Fly   329 RVVWKTE--LYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVF 391

  Fly   382 CDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAI 446
            .|..:|.....:.|.|..||...::...|...|.|::.||||...|:...:.|.|:..:.||||:
  Fly   392 FDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAV 456

  Fly   447 YWTEYVLRHNGAYHLQTPSRNMTW---WQYYLL-----DVV---AVYLIL-LYVLILALRRIDFP 499
            :||||.||:..|.|::..:.::..   |.:.||     .:|   .:||:. |:....|.||   |
  Fly   457 WWTEYALRNKDASHMRLNTEDVPLYYEWDWGLLLGLRFGIVFGSVIYLVYKLFQKTSARRR---P 518

  Fly   500 YE 501
            ::
  Fly   519 FQ 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	116/431 (27%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	93/316 (29%)
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	132/463 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.970