DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt37A3

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_650229.2	Gene:	Ugt37A3 / 41574	FlyBaseID:	FBgn0038083	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	153/556 - (27%)
Similarity:	263/556 - (47%)	Gaps:	61/556 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKKIALFLIIWSCGTLAADILMATQGG----------TKSHKIPFWELAKGLISRGHNITFLSG 55
            |:.::..||::    .:|...:|.:..|          :.||.|.....||.|...|||:|.::.
  Fly     1 MVLRVEKFLLL----AIAIGAVMGSSQGANILGLFPSLSPSHLIIQMSAAKVLAENGHNVTVVTV 61

  Fly    56 FPADFNIEGLLEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAMLR-DSET- 118
            .....|.:.:..:......|.....:  |.:|:....:........||.: :..|.|:| ::||
  Fly    62 LKPVVNHKNITVIQVPLSKEEAQQMS--DTIGAMSKNDNSNMALSLLRMS-DQMDFMIRKNAETL 123

  Fly   119 -----KEL---TKKSFDLAILDGAFPECF-LGLMYDFKIPFMYINTVGFYTGSISTAGNP--VSY 172
                 ::|   ....||| ::.|.|...| ||.......|.:.:.|:..........|||  |||
  Fly   124 MNDRVRDLYLNRGNKFDL-VISGYFMNDFQLGFARKVNAPVIVLATMPPNHLLNPLIGNPLEVSY 187

  Fly   173 A--ITPNFYSRFTDTMNLYERAINTAMQ-IGQTLMHMYVMRRTHLVMREHLGT--QIPHPYEMSR 232
            |  ..|...|:..    .::|.:::.|| :|..:......||.....:|..|.  ::|...||.:
  Fly   188 AGISNPAEGSKAV----TFQRRLSSYMQSLGFGVFSHLSERRNRNWYKEVYGNDPKMPEYSEMLK 248

  Fly   233 NVSFILQNGHAVLSYP-RAFNPNVAEVACIHCR-PARKLPRNLEEFIGASGASGFIYVSMGSSVK 295
            |.|.:..:.||....| |...|:..|:..|..: ....||:|:.||:| :...|.|.:|:||:|:
  Fly   249 NTSLVFFSSHAASEGPIRPNVPSAIEIGGIQIKDKPDPLPQNIAEFLG-NATDGAILLSLGSNVQ 312

  Fly   296 AANM-PEALRHMLVKTFARLPYHVLWKYEG-SSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVT 358
            ..:: |:.:..|. ...::|...|:||:|. .:|..|  ::|:..|:||||.|||.||.::.|:.
  Fly   313 GKHLNPDTVAKMF-NVLSKLKERVIWKWEDQENTPGK--SANILYSKWLPQDDILAHPNIKLFIN 374

  Fly   359 HGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRY 423
            |.|...:.|:.|||.|::::|||.|...|:......|:.:.|.|.||......:||::::.||:|
  Fly   375 HAGKGGITESQYHGKPMLSLPVFADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQY 439

  Fly   424 RNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDV-VAVYLILLY 487
            ....:....|:.|:..||.::.:||||||:||:||.|||:|..:|::.....:|: ..:::||:.
  Fly   440 AERVKSFSTLYRDRPMTARESFLYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDICFLIFVILVS 504

  Fly   488 VLILALRRIDFPYEKVRSLYSLMAPFITIAKTKSKK 523
            ||:|....:.|.|.:.            |:|.|.:|
  Fly   505 VLVLIKFLVQFIYRRF------------ISKPKKEK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	117/437 (27%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	99/316 (31%)
Ugt37A3	NP_650229.2	egt	1..490	CDD:223071	141/504 (28%)
Ugt37A3	NP_650229.2	UDPGT	37..526	CDD:278624	145/512 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BZ0V
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.920