DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt35A1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	169/532 - (31%)
Similarity:	276/532 - (51%)	Gaps:	67/532 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IALFLIIWSCGTLAADILMATQGGTKSHKI----PF---------WELAKGLISRGHNITFLSGF 56
            |.|..:||.....|.:       |.:|.:|    ||         .:..|.|..||||:|.::.|
  Fly    12 ILLIGLIWLFAANADE-------GVQSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTF 69

  Fly    57 PAD-----FNIEG---LLEVTPA-GLVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAM 112
            .:|     |.:.|   :.|:..| |..:|....:.|.:|...            .::......::
  Fly    70 GSDKNEPNFRVIGAKKIHEIMAAFGNADYTQTASQWQMLTMT------------TQFLNLLTTSI 122

  Fly   113 LRDSETKEL--TKKSFDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSISTAGN--PVSYA 173
            |.|:..|:|  :.:.|||.|::....|...||:..|....:.|::.|..|......||  |:||
  Fly   123 LDDAAVKDLLNSGEKFDLVIMEAVQTEALFGLIQHFGAETIGISSYGTDTHIDELMGNISPLSY- 186

  Fly   174 ITPNFYSRFTDTMNLYERAIN----TAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNV 234
             .|...|..|:.|:..:|.:|    :.|.:.:.::|:...|..:   .::..|......|:..:.
  Fly   187 -NPLLLSSRTEQMDFKDRVMNVFEASVMWLHKRIVHLPSQRDLY---AKYFPTARKSLDEVLDSF 247

  Fly   235 SFILQNGHAVLSYPRAFNPNVAEVACIHCRPARK---LPRNLEEFIGASGASGFIYVSMGSSVKA 296
            :.:|...|..|||||.:.||:.||..:|.:..||   |.:.|.||:..| ..|.||.||||::|:
  Fly   248 ALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKRKVQPLAKELSEFVEQS-EKGVIYFSMGSNIKS 311

  Fly   297 ANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGG 361
            .::|.:.|.||::|||.:|..||||:|  ...:.:...||.:|:|.||.|||.||.::.|:||||
  Fly   312 KDLPPSTRKMLMQTFASVPQRVLWKFE--DDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGG 374

  Fly   362 LLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNS 426
            |||..|::|.|.|::.:|:|.|..:|..:|:..||.:..|:.:::|.:|...|.:::.||.|..:
  Fly   375 LLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAA 439

  Fly   427 ARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLD-------VVAVYLI 484
            |:.:.|||.||:.|||:.||:||||||||.||.||:..||::.:.|::.||       :..|.|:
  Fly   440 AQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLL 504

  Fly   485 LLYVLILALRRI 496
            ::.:||..|:|:
  Fly   505 IVVILIKCLQRV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	132/438 (30%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	117/320 (37%)
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	153/481 (32%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	158/482 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.920