DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt35B1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	177/541 - (32%)
Similarity:	272/541 - (50%)	Gaps:	51/541 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KIALFLIIWSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPADFNIEGLLEV 68
            :|...|:.......||.||........|..|......|.|.:|||.:|.::.||....:....:|
  Fly     5 RIGFLLLTLPASMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNFRDV 69

  Fly    69 TPAGLVEYIHN-YTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAMLRDSET-KELT-------KK 124
                   :|.: :.|:..|.:.::|  |:..|....:..:...::.|...| ||:|       |.
  Fly    70 -------FIPDVFNNYKELINELSG--PMNLWQENNFINKFFVSVTRCVLTNKEVTETLLPPGKD 125

  Fly   125 SFDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSISTAGN--PVSYAITPNFYSRFTDTMN 187
            .|||.|::....:.:.|....|..|.:.|:|.|......:..||  |:||  ||......||.|.
  Fly   126 HFDLIIVEALRSDAYYGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSY--TPLATGGLTDRMT 188

  Fly   188 LYERAIN----TAMQIGQTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNGHAVLSYP 248
            ..||..|    |...:....:||....:.:.........:: ...:::||.|.:|.|.|..||:|
  Fly   189 FLERLSNFVDTTVAWLNYRFVHMSEQEKMYAKYFPEASKRV-QLTDLNRNFSLVLLNQHFSLSFP 252

  Fly   249 RAFNPNVAEVACIHC--RPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTF 311
            |.:.||:.||..:|.  :|| .||::|||||..||..|.||.|:||:|.:.::|...:.:::|||
  Fly   253 RPYVPNMIEVGGLHISHKPA-PLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTF 316

  Fly   312 ARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVV 376
            |.||..||||:|......|  .|||.:|:|.||.|||.|||::.|:|||||||..|:::||.||:
  Fly   317 ASLPQRVLWKFEDDKLPGK--PSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVL 379

  Fly   377 TMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTA 441
            .:|.|.|..:|..:|...|:.:.||..|::..:|.:.|..::..||:...||...:.:.||..:.
  Fly   380 GLPFFYDQFLNVRRATQAGFGLGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPMSP 444

  Fly   442 LDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYL---ILLYVLILAL--RRIDFPYE 501
            |||||:||||||||.||||::...:::.::.|:.|||:.|.|   :||..:|:.:  :..||...
  Fly   445 LDTAIWWTEYVLRHKGAYHMRVAGQDLGFFAYHSLDVIGVLLGGALLLVAIIVGVLGKLTDFGNA 509

  Fly   502 KVRSLYSLMAPFITIAKTKSK 522
            |              .|.|||
  Fly   510 K--------------KKLKSK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	136/422 (32%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	121/312 (39%)
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	160/472 (34%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	136/426 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.910