DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt49C1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	148/524 - (28%)
Similarity:	252/524 - (48%)	Gaps:	71/524 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GTLAADILMATQGGT---------KSHKIPFWELAKGLISRGHNITFLSGFPAD----------- 59
            |||.:.:.:| :|..         |||.:....|.:.|:..||.:|.::.|..:
  Fly    13 GTLYSQLELA-EGSKILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAFSLEKEQLGSNYTEI 76

  Fly    60 ---------------FNIEGLLEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKPWDGLRYAFESC 109
                           |..:.|.|:|         ..||:|.|  :|...:.:|          :.
  Fly    77 LIEPVYDFWHDVKLNFGAQHLFELT---------RMTNYDFL--KMLEIIGLK----------TT 120

  Fly   110 DAMLRDSETKELTKKS-----FDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSISTAGNP 169
            :..||..:.:.|....     |||.:.:..:.|.||.|.:.:|||.:..:|:|:........|..
  Fly   121 EHALRQPKVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLI 185

  Fly   170 VSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMY-VMRRTHLVMREHLG---TQIPHPYEM 230
            ..::..|:.:..|||.|:..||..|:.....:.:..:. ...:...|.||..|   |::|....|
  Fly   186 TPWSFVPHGFMPFTDRMSFLERVKNSYASFYEDMDRLLNYFPKMDAVAREFFGPVLTEVPKVKHM 250

  Fly   231 SRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFI-GASGASGFIYVSMGSSV 294
            .|.:|.:|.|.||.|:..|.....:..|..:|..|.:.||.:::..: ||:  .|.|:.|:||:|
  Fly   251 ERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGAT--EGAIFFSLGSNV 313

  Fly   295 KAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTH 359
            ::.:||..:..:.::.|..|...||||:|..|  |..:..||.:.:||||.|||.|..::.|:||
  Fly   314 QSKDMPVEMLRLFLQVFGSLKQRVLWKFEDES--ISQLPDNVMVRKWLPQADILAHRHVKVFITH 376

  Fly   360 GGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYR 424
            |||....|.|::.||::.:|.:||..:|..||.:.||||.|..|:::...|..::.::|||..|:
  Fly   377 GGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITEEILRHSLDQLIHNVTYK 441

  Fly   425 NSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLILLYVL 489
            .:.:....:|.|:......:|:||.|||:||.||.|:::...::.|:|:|||||:|...|:....
  Fly   442 ENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAIIALAG 506

  Fly   490 ILAL 493
            ::||
  Fly   507 VMAL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	119/450 (26%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	103/311 (33%)
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	143/507 (28%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	138/485 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.960