DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt49B1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	178/566 - (31%)
Similarity:	280/566 - (49%)	Gaps:	78/566 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKKIALFLIIWSCGTL-------AADILMATQGGTKSHKIPFWELAKGLISRGHNITFLSGFPA 58
            |..|.||.:.:.|...|       .:.||.|.....|||.:....:.:.|:.:||.:||::.|..
  Fly     1 MSLKSALHIFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSL 65

  Fly    59 -----------------DF--------NIEGLLEVTPAGLVEYIHNYTNWDLLGSRMAGEMPIKP 98
                             ||        |...:||:|......::           ||...|.|..
  Fly    66 AKEKLGSNYKEIVIPQYDFWPEIKEMTNKNTVLEMTDLPTFAFL-----------RMVNVMGIHT 119

  Fly    99 WDGLRYAFESCDAMLRDSETKELTKKSFDLAILDGAFPECFLGLMYDFKIPFMYINTVG--FYTG 161
            .|   :|.|..:.....:|..::.|  :||.:.:..|.|..|.|.:.::||.:.|:|.|  .:..
  Fly   120 TD---FALEQPEIQAVINEKNKIGK--YDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLS 179

  Fly   162 SISTAGNPVSYAITPNFYSRFTDTMNLYERAINTAMQIGQTLMHMY-VMRRTHLVMREH---LGT 222
            .:....:|.||  .|:.|..:||.|.|:||..|.||...:.|:..: .......|:::|   |..
  Fly   180 QLFGVVSPWSY--VPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLD 242

  Fly   223 QIPHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGAS-GFI 286
            ::|...|:.||:|.||.|.:..|:..|....|:..|..:|.:|.:.||.:|::|:  .||: |.|
  Fly   243 RVPTIKELERNISAILLNSYMPLASSRPMAYNMIPVGGLHIQPPKALPEHLQKFL--DGATHGAI 305

  Fly   287 YVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHP 351
            |.|:||.|::|::|.....:.::.|..|...||||:|..|  :.::.:|||:..||||.|||.||
  Fly   306 YFSLGSQVRSADLPPEKLKVFLEVFGSLKQRVLWKFEDES--LPNLPANVKVQSWLPQGDILAHP 368

  Fly   352 KLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMK 416
            .::.|:.||||....|.||:|||::.|||:||...|..:.:...||:.||.:.::..:|...:|:
  Fly   369 NVKVFIAHGGLFGTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLME 433

  Fly   417 VIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVV-- 479
            :|.||:|||:.:...::|.|:...|:||||||..||:.|.||.||.....::.|:|:||||:|
  Fly   434 LIENPKYRNNIKKASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGL 498

  Fly   480 --AVYLILLYVLILALRRIDFPYEKVRSLYSLMAPFITIAKTKSKK 523
              ||.|:.:.||||..||...|..             |..|.|:||
  Fly   499 GLAVILLPIVVLILICRRSSKPKS-------------TPTKKKTKK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	131/437 (30%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	116/311 (37%)
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	166/527 (31%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	160/498 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.960