DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt36E1

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_609911.1	Gene:	Ugt36E1 / 35139	FlyBaseID:	FBgn0027070	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	496	Identity:	133/496 - (26%)
Similarity:	238/496 - (47%)	Gaps:	58/496 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SHKIPFWELAKGLISRGHNITFLSGF----PADFNIEGLLEVTPAGLVE------------YIHN 79
            ||...|..:.:||...||::..:|.|    |.:...:.||  .|:.|.:            ::.:
  Fly    35 SHFKFFHPIMRGLAEAGHSVDVISPFEDKDPPNGYKDHLL--PPSTLTDTISLEDFERPYSFLFH 97

  Fly    80 YTNWDLLGSRMAGEMPIKPWDGLRYAFESCDAMLRDSETKELTKKS---FDLAILDGAFPECFLG 141
            |..:.:|.               :...|.|:..|......|:.|..   :|:.:|:....:|.:.
  Fly    98 YVEFFILH---------------KMGREDCNTTLHSRALTEILKNPPGYYDVILLEQFNTDCAMS 147

  Fly   142 LMYDFKIPFMYINTVGFYTGSISTAGNPVSYAITPNFYSRFTDTMNLYERAINTAMQIG------ 200
            :.:.|:.|.:.:::...........|.|    :.|::.|......:   :.::.|.::|
  Fly   148 VAHVFQAPVIGMSSCALMPWHYERFGAP----LIPSYISALFQGQS---QEMSFAGRLGNWITVH 205

  Fly   201 --QTLMHMYVMRRTHLVMREHLGTQIPHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHC 263
              ..|..|:.:...:.::|:..|..:|...::.||.|.:|.|.|..||.|:...|||.||..:|.
  Fly   206 SLNLLYKMFTVPAGNALIRQRFGPGLPSTEDLVRNTSLMLVNQHFSLSGPKPLPPNVIEVGGVHI 270

  Fly   264 RPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTD 328
            .|.:.||.:|::.:. :...|.|.:|.||.:||.::..|.|..:||...||...|:||||..:..
  Fly   271 SPPKPLPSDLQKILD-NAPKGVILISWGSQLKACSLSAARRDGIVKAIGRLEQEVIWKYENDTLP 334

  Fly   329 IKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEV 393
            .|  ..|:.:.:||||:|||.||.|:.|::||||:...|.|...||:|.:|::.|..:|.|....
  Fly   335 NK--PPNLHIRKWLPQRDILAHPNLKVFMSHGGLMGTTEAVSSAVPIVGVPIYGDQSLNIAALVQ 397

  Fly   394 DGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGA 458
            .|.|::|:|:.|..|.:|:|:.|.: :|.::..|:.....:.::....|:|||:|.|:|....||
  Fly   398 RGMALQLELKKLDENTVYEALTKAL-DPSFKARAKEVASSYNNRIQGPLETAIWWVEHVAETKGA 461

  Fly   459 YHLQTPSRNMTWWQYYLLD---VVAVYLILLYVLILALRRI 496
            ...|..:.:::.:.||.||   |||:.|:|..:.:|.|.|:
  Fly   462 PLTQPSAVHLSRFVYYSLDVYSVVALSLLLPVITLLGLIRM 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	111/429 (26%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	97/317 (31%)
Ugt36E1	NP_609911.1	egt	3..460	CDD:223071	118/452 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	1	0.950	-	0.678979	Normalized mean entropy	S5661
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.910