DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt50B3 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	150/526 - (28%)
Similarity:	238/526 - (45%)	Gaps:	79/526 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IALFLIIWSCGTLAADILMATQGGTKSHKIPFWELAKGLISRGHNITFL-------SGFPADFNI 62
            :.|||.  |....|..:|:....|  ||......:.:.|..|||.:..:       .|...:|.:
  Rat    14 VCLFLA--SGFAQAGRLLVVPMDG--SHWFTMQMIVEKLSHRGHEVVVVIPEVSWHMGKSLNFTV 74

  Fly    63 EGLLEVTPAGLVEYIHNYTNWDL-----------LGSRMAGEMPIKPWDG---LRYAFESCDAML 113
            :           .|..:||..||           ..::..|...:....|   ....|..|.::.
  Rat    75 K-----------TYSVSYTLEDLNYHFKFFAHNQWKTQEVGMFSLLKHSGKGFFELLFSHCRSLF 128

  Fly   114 RDSETKE-LTKKSFDLAILDGAFPECFLGLMYDFKIPFMYINTVGF--YTGSISTAGNPVSYAIT 175
            :|.:..| |.:.|||...|| .|..|.|.|...|.:|.:..:...|  |....:...:|.||  .
  Rat   129 KDKKLVEYLKQSSFDAVFLD-PFDVCGLILAKYFSLPSVVFSGGIFCHYLDEGAQCPSPPSY--V 190

  Fly   176 PNFYSRFTDTMNLYERAIN----------------TAMQIGQTLMHMYVMRRTHLVMREHLGTQI 224
            |...|:|||||...||..|                ||::|...::      :|.:.||
  Rat   191 PRILSKFTDTMTFKERVWNHLSYMKERAFCPYFFKTAVEIASEVL------QTPVTMR------- 242

  Fly   225 PHPYEMSRNVSFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVS 289
                ::...||..:.....||.:||...||:..:..|:|...:.|.:..|.::.|||..|.:..|
  Rat   243 ----DLFSPVSIWMFRTDFVLEFPRPVMPNMVYIGGINCHQGKPLSKEFEAYVNASGEHGIVVFS 303

  Fly   290 MGSSVKAANMPEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLR 354
            :||.|  :.:||.....:.:...|:|..|||:|.|  |...::..|..|.:||||.|:|||||.|
  Rat   304 LGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG--TRPSNLAKNTILVKWLPQNDLLGHPKAR 364

  Fly   355 AFVTHGGLLSMFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIH 419
            ||:||.|...::|.:.:|||:|.||:|.|...|:.:.|..|..:.|::..::|:.|..|:..||:
  Rat   365 AFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVIN 429

  Fly   420 NPRYRNSARHRQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLI 484
            |..|:.:......|..|:....||.|::|.|||:||.||.||:..:.::||:||:.|||:...|.
  Rat   430 NKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLA 494

  Fly   485 LLYVLI 490
            ::..::
  Rat   495 IVLTVV 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	121/445 (27%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	106/322 (33%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	145/512 (28%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	86/242 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm44525
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810